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Titolo:
A NOVEL INTERLEUKIN-12 P40-RELATED PROTEIN-INDUCED BY LATENT EPSTEIN-BARR-VIRUS INFECTION IN B-LYMPHOCYTES
Autore:
DEVERGNE O; HUMMEL M; KOEPPEN H; LEBEAU MM; NATHANSON EC; KIEFF E; BIRKENBACH M;
Indirizzi:
UNIV CHICAGO,KOVLER VIRAL ONCOL LABS,910 E 58TH ST CHICAGO IL 60637 UNIV CHICAGO,DEPT MED CHICAGO IL 60637 UNIV CHICAGO,DEPT PATHOL CHICAGO IL 60637 UNIV CHICAGO,CANC RES CTR CHICAGO IL 60637 BRIGHAM & WOMENS HOSP BOSTON MA 02115 HARVARD UNIV,DEPT MICROBIOL & MOLEC GENET BOSTON MA 02115 HARVARD UNIV,DEPT MED BOSTON MA 02115
Titolo Testata:
Journal of virology
fascicolo: 2, volume: 70, anno: 1996,
pagine: 1143 - 1153
SICI:
0022-538X(1996)70:2<1143:ANIPPB>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
AUTOCRINE GROWTH-FACTOR; CELL-LINES; BURKITTS-LYMPHOMA; RECEPTOR SUPERFAMILY; INVITRO INFECTION; ACTIVATION; GENE; EXPRESSION; CYTOKINE; IDENTIFICATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
66
Recensione:
Indirizzi per estratti:
Citazione:
O. Devergne et al., "A NOVEL INTERLEUKIN-12 P40-RELATED PROTEIN-INDUCED BY LATENT EPSTEIN-BARR-VIRUS INFECTION IN B-LYMPHOCYTES", Journal of virology, 70(2), 1996, pp. 1143-1153

Abstract

We have isolated a cDNA encoding a novel hematopoietin receptor family member related to the p40 subunit of interleukin-12 and to the ciliary neurotrophic factor receptor, whose expression is induced in B lymphocytes by Epstein-Barr virus (EBV) infection, This gene, which we have designated EBV-induced gene 3 (EB13), encodes a 34-kDa glycoprotein which lacks a membrane-anchoring motif and is secreted, Despite the absence of a membrane-anchoring motif and of cysteines likely to mediatecovalent linkage to an integral membrane protein, EBI3 is also present on the plasma membrane of EBV-transformed B lymphocytes and of transfected cells. Most newly synthesized EBI3 is retained in the endoplasmic reticulum in an endoglycosidase H-sensitive form associated with the molecular chaperone calnexin and with a novel 60-kDa protein, EBI3 is expressed in vivo by scattered cells in interfollicular zones of tonsil tissue, by cells associated with sinusoids in perifollicular areasof spleen tissue, and at very high levels by placental syncytiotrophoblasts. EB13 expression in vitro is induced in EBV-negative cell linesby expression of the EBV latent infection membrane protein-1 and in peripheral blood mononuclear cells by pokeweed mitogen stimulation, EB13 maps to chromosome 19p313.2/3, near genes encoding the erythropoietin receptor and the cytokine receptor-associated kinase, Tyk2, EBI3 synthesis by trophoblasts and by EBV-transformed cells and similarities to interleukin-12 p40 are compatible with a role for EBI3 in regulatingcell-mediated immune responses.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 22:30:10