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Titolo:
RENAL TUBULAR PROTEIN-DEGRADATION OF RADIOLABELED APROTININ (TRASYLOL) IN PATIENTS WITH CHRONIC-RENAL-FAILURE
Autore:
RUSTOM R; GRIME JS; MALTBY P; STOCKDALE HR; JACKSON MJ; CRITCHLEY M; BONE JM;
Indirizzi:
ROYAL LIVERPOOL UNIV HOSP,REG RENAL UNIT,LINK 6C,PRESCOT ST LIVERPOOLL7 8XP ENGLAND ROYAL LIVERPOOL UNIV HOSP,REG RENAL UNIT,LINK 6C,PRESCOT ST LIVERPOOLL7 8XP ENGLAND ROYAL LIVERPOOL UNIV HOSP,DEPT NUCL MED LIVERPOOL ENGLAND ROYAL LIVERPOOL UNIV HOSP,DEPT MED LIVERPOOL ENGLAND
Titolo Testata:
Clinical science
fascicolo: 6, volume: 85, anno: 1993,
pagine: 733 - 736
SICI:
0143-5221(1993)85:6<733:RTPORA>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMMONIA; METABOLISM; RAT;
Keywords:
APROTININ; CHRONIC RENAL FAILURE; RENAL TUBULAR PEPTIDE METABOLISM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
R. Rustom et al., "RENAL TUBULAR PROTEIN-DEGRADATION OF RADIOLABELED APROTININ (TRASYLOL) IN PATIENTS WITH CHRONIC-RENAL-FAILURE", Clinical science, 85(6), 1993, pp. 733-736

Abstract

1. The new method developed to measure renal tubular degradation of small filtered proteins in patients with normal renal function, using radiolabelled aprotinin (Trasylol) (R. Rustom, J. S. Grime, P. Maltby, H. R. Stockdale, M. Critchley, J. M. Bone. Clin Sci 1992; 83, 289-94),was evaluated in patients with chronic renal failure. 2. Aprotinin was labelled with either Tc-99m (40 MBq) or I-131 (0.1 MBq), and injected intravenously in nine patients, with different renal pathologies. Cr-51-EDTA clearance (corrected for height and weight) was 40+/-5.4 (range 11.2-81) ml min-1 1.73 m-2. Activity in plasma and urine was measured over 24-48 h, and chromatography on Sephadex-G-25-M was used to separate labelled aprotinin from free (TcO4-)-Tc-99m or I-131. Renal uptake was measured for Tc-99m-labelled aprotinin only. 3. The volume of distribution was 20.2+/-2.3 litres. Chromatography showed all plasma activity as undegraded aprotinin, and urine activity only as the free labels (TcO4-)-Tc-99m or I-131). 4. As in patients with normal renal function, activity in the kidney appeared promptly, with 5.7+/-2.5% of the dose detected even at 5 min. Activity rose rapidly to 9.4+/-1.6% of dose after 1.5 h, then more slowly to 15.0+/-0.5% of dose at 4.5 h, and even more slowly thereafter, reaching 24.1+/-2.8% of dose at 24 h. Extra-renal uptake was again insignificant, and both (TcO4-)-Tc-99m andI-131- appeared promptly in the urine, with similar and uniform ratesof excretion over 24h. 5. Both tubular uptake at 24h and the rate of tubular metabolism over 24h were lower than in the patients with normal renal function studied previously, but only the rate of tubular metabolism was directly related to the glomerular filtration rate (r=0.75,P < 0.02). 6. Correction for the reduced glomerular filtration rate yielded values for both tubular uptake (0.67+/-0.14 versus 0.32+/-0.03%of dose/ml of glomerular filtration rate, P<0.005), and tubular metabolism (0.033+/-0.07 versus 0.015+/-0.00.1% of dose h-1 ml-1 of glomerular filtration rate, P<0.005) that were higher by comparison with those for patients with normal renal function studied previously. 7. Fractional renal degradation of Tc-99m-aprotinin (in h-1), derived from themean rate of urinary excretion of the free isotope over a given interval, divided by the mean cumulative kidney uptake over the same interval, also fell steeply early, and then more slowly to 0.07+/-0.01 h-1 at 14.25 h (between 4.5 and 24 h). 8. It is concluded that the method described previously is also suitable in patients with chronic renal failure, allowing further research into renal disease progression.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/10/20 alle ore 15:17:01