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Titolo:
EFFECTS OF LITHIUM AND MYOINOSITOL ON THE RAT BISECTED VAS-DEFERENS
Autore:
QUEIROZNETO A; MATAQUEIRO MI; BALLEJO G;
Indirizzi:
UNESP,FAC AGRON & VET SCI,DEPT ANIM MORPHOL & PHYSIOL BR-14870000 JABOTICABAL BRAZIL USP,FAC MED BR-05508 RIBEIRAO PRET BRAZIL
Titolo Testata:
General pharmacology
fascicolo: 8, volume: 26, anno: 1995,
pagine: 1735 - 1739
SICI:
0306-3623(1995)26:8<1735:EOLAMO>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE; NOREPINEPHRINE; NORADRENALINE; RESPONSES; MESSENGER; BRAIN;
Keywords:
LITHIUM; MYOINOSITOL; SMOOTH MUSCLE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
A. Queirozneto et al., "EFFECTS OF LITHIUM AND MYOINOSITOL ON THE RAT BISECTED VAS-DEFERENS", General pharmacology, 26(8), 1995, pp. 1735-1739

Abstract

1. The effects of lithium (Li+) on the concentration-response curves (CRC) to norepinephrine (NE) and acetylcholine (Ach) on the bisected rat vas deferens (RVD) were investigated, as well as its action on the neuronal uptake of [H-3] NE. 2. Li+ did not affect the 50% effective concentration (EC(50)) of NE and Ach in the epididymal (EP) portion of the RVD. 3. Li+ caused a significant increase of the EC(50) to NE and Ach in the prostatic (PP) portion of the RVD. This shift to the right of the CRC to NE was prevented by the presence of myoinositol. 4. Incubation of the PP of the RVD with Li+, increased the neuronal uptake ofNE. The simultaneous incubation with myoinositol prevented this increase. 5. After the pre-treatment of the rats with 6-hydroxydopamine (6-OHDA), or in the presence of cocaine, Li+ failed to desensitize the PPof the RVD to NE. 6. These results suggest that the effect of Li+ on the PP of the RVD occurs mainly at the pre-synaptic level and may be related to the increase of neuronal uptake and to the interference of Li+ on phosphatidylinositol hydrolysis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 10:53:01