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Titolo:
EFFECT OF THE INTRAPERITONEAL ADMINISTRATION OF SALMON-CALCITONIN ON THE IN-VITRO ACTIONS OF OPIOID AGONISTS
Autore:
MARTIN MI; GOICOECHEA C; ORMAZABAL MJ; ALFARO MJ;
Indirizzi:
UNIV COMPLUTENSE MADRID,FAC MED,DEPT FARMACOL E-28040 MADRID SPAIN
Titolo Testata:
General pharmacology
fascicolo: 8, volume: 26, anno: 1995,
pagine: 1695 - 1699
SICI:
0306-3623(1995)26:8<1695:EOTIAO>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOUSE VAS-DEFERENS; RECEPTORS; ANALGESIA; MORPHINE;
Keywords:
GUINEA PIG ILEUM; MOUSE VAS DEFERENS; OPIOID RECEPTOR SUBTYPES; RABBIT VAS DEFERENS; SALMON-CALCITONIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
M.I. Martin et al., "EFFECT OF THE INTRAPERITONEAL ADMINISTRATION OF SALMON-CALCITONIN ON THE IN-VITRO ACTIONS OF OPIOID AGONISTS", General pharmacology, 26(8), 1995, pp. 1695-1699

Abstract

1. The interaction of intraperitoneal administration of salmon-calcitonin with opioids was studied. The study was carried out using guinea pig ileum (mu and kappa-opioid receptors), rabbit vas deferens (kappa-opioid receptors) and mouse vas deferens (delta-opioid receptors), and selective mu, delta and kappa agonists were used in the pertinent tissues. 2. The treatment with salmon-calcitonin increased, in a dose-dependent manner, the effect of U-50,488H in guinea pig ileum and rabbitvas deferens and the effects of [D-Pen(2), D-Pen(5)] enkephalin in mouse vas deferens. 3. The treatment with analgesic doses of salmon-calcitonin enhances the in vitro effects of kappa- and delta-opioid agonists. The increase of the effectiveness of the opioid agonists may be one of the mechanisms involved on the analgesia induced by salmon-calcitonin.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 11:15:09