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Titolo:
ESTROGEN-RECEPTOR - A STABLE PHENOTYPE IN BREAST-CANCER
Autore:
ROBERTSON JFR;
Indirizzi:
CITY HOSP NOTTINGHAM,HUCKNALL RD NOTTINGHAM NG5 1PB ENGLAND
Titolo Testata:
British Journal of Cancer
fascicolo: 1, volume: 73, anno: 1996,
pagine: 5 - 12
SICI:
0007-0920(1996)73:1<5:E-ASPI>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
TAMOXIFEN-STIMULATED GROWTH; STEROID-HORMONE RECEPTORS; DUCTAL CARCINOMA INSITU; ESTROGEN-RECEPTOR; ENDOCRINE THERAPY; PROGESTERONE-RECEPTOR; IMMUNOCYTOCHEMICAL ASSAY; CLINICAL-PHARMACOLOGY; MONOCLONAL-ANTIBODIES; C-ERBB-2 ONCOPROTEIN;
Keywords:
BREAST CANCER; ESTROGEN RECEPTOR; STABLE PHENOTYPE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
115
Recensione:
Indirizzi per estratti:
Citazione:
J.F.R. Robertson, "ESTROGEN-RECEPTOR - A STABLE PHENOTYPE IN BREAST-CANCER", British Journal of Cancer, 73(1), 1996, pp. 5-12

Abstract

Oestrogen receptor (ER) expression in breast cancer is regarded as a phenotype that may change during the natural history of the disease orduring endocrine therapy. II has been suggested that in up to 70% of tumours that show acquired resistance the mechanism may be changed in ER status from positive to negative. This paper proposes an alternative hypothesis that ER expression is a stable phenotype in breast cancer. The paper reviews the literature on ER expression during the naturalhistory of breast cancer in patients and also presents data on the effect of endocrine therapy on ER expression. If the alternative hypothesis is true it has important implications for treatment from chemoprevention to acquired endocrine resistance in advanced disease. Equally, if the hypothesis is true, attempts to develop laboratory models of endocrine resistance where ER-positive tumours become ER negative need to be re-evaluated.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 12:57:40