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Titolo:
MOLECULAR CHARACTERIZATION OF A CDNA-ENCODING FUNCTIONAL HUMAN DEOXYHYPUSINE SYNTHASE AND CHROMOSOMAL MAPPING OF THE CORRESPONDING GENE LOCUS
Autore:
BEVEC D; KAPPEL B; JAKSCHE H; CSONGA R; HAUBER J; KLIER H; STEINKASSERER A;
Indirizzi:
SANDOZ GMBH,RES INST,BRUNNER STR 59 A-1235 VIENNA AUSTRIA SANDOZ GMBH,RES INST A-1235 VIENNA AUSTRIA
Titolo Testata:
FEBS letters
fascicolo: 2, volume: 378, anno: 1996,
pagine: 195 - 198
SICI:
0014-5793(1996)378:2<195:MCOACF>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
EUKARYOTIC INITIATION FACTOR-5A; HYPUSINE;
Keywords:
EUKARYOTIC INITIATION FACTOR 5A; HYPUSINE FORMATION; POSTTRANSLATIONAL MODIFICATION; CHROMOSOMAL MAPPING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
12
Recensione:
Indirizzi per estratti:
Citazione:
D. Bevec et al., "MOLECULAR CHARACTERIZATION OF A CDNA-ENCODING FUNCTIONAL HUMAN DEOXYHYPUSINE SYNTHASE AND CHROMOSOMAL MAPPING OF THE CORRESPONDING GENE LOCUS", FEBS letters, 378(2), 1996, pp. 195-198

Abstract

Deoxyhypusine synthase is essentially required for the post-translational formation of hypusine, a modification of a specific lysine residue in eukaryotic initiation factor 5A, which appears to be pivotal for cell proliferation, From a human peripheral blood mononuclear cells cDNA library we isolated two independent sequences encoding biologicallyactive deoxvhypusine synthase, DNA sequence analysis revealed a 369 amino acid protein with a molecular mass of 41.055 kDa, This recombinant deoxyhypusine synthase showed significant catalytic activity in synthesis of deoxyhypusine after in vitro transcription and translation aswell as upon expression in Escherichia coli, Using a panel of somaticrodent-human cell hybrids we localized the deoxyhupusine synthase gene to human chromosome 19.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 22:34:45