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Titolo:
NOVEL ANTIINFLAMMATORY COMPOUNDS PREVENT CD11B CD18, ALPHA(M)BETA(2) (MAC-1)-DEPENDENT NEUTROPHIL ADHESION WITHOUT BLOCKING ACTIVATION-INDUCED CHANGES IN MAC-1/
Autore:
ENDEMANN G; FENG Y; BRYANT CM; HAMILTON GS; PERUMATTAM J; MEWSHAW RE; LIU DY;
Indirizzi:
SCIOS NOVA INC,2450 BAYSHORE PKWY MT VIEW CA 94043
Titolo Testata:
The Journal of pharmacology and experimental therapeutics
fascicolo: 1, volume: 276, anno: 1996,
pagine: 5 - 12
SICI:
0022-3565(1996)276:1<5:NACPCC>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
FUNCTION-ASSOCIATED ANTIGEN-1; LEUKOCYTE DIFFERENTIATION; MONOCLONAL-ANTIBODIES; CHEMOTACTIC FACTORS; SURFACE EXPRESSION; ENDOTHELIAL-CELLS; COUNTER-RECEPTOR; BETA-SUBUNIT; LFA-1; NPC-15669;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
G. Endemann et al., "NOVEL ANTIINFLAMMATORY COMPOUNDS PREVENT CD11B CD18, ALPHA(M)BETA(2) (MAC-1)-DEPENDENT NEUTROPHIL ADHESION WITHOUT BLOCKING ACTIVATION-INDUCED CHANGES IN MAC-1/", The Journal of pharmacology and experimental therapeutics, 276(1), 1996, pp. 5-12

Abstract

Leumedins are small organic molecules with anti-inflammatory properties in vivo, We report here that leumedins inhibit the CD11b/CD18 alpha(M) beta(2) (Mac-1)-dependent adherence of neutrophils to serum proteins. The activation of neutrophils leading to adherence via Mac-1 is associated with an increase in cell surface Mac-1 level, and with an increased affinity of Mac-1 for adhesion partners. Inhibition of neutrophil adherence by leumedins does not require blocking the recruitment ofMac-1 from intracellular granules to the cell surface. Furthermore, leumedins do not block the expression on Mac-1 of the epitope for an ''activation-specific'' antibody (CBRM1/5). Time course studies show that leumedins inhibit adherence by targeting an event which occurs concurrently with changes in Mac-I level and induction of the CBRM1/5 epitope. Therefore, leumedins block an unknown process which is permissive for Mac-1-dependent adherence.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/21 alle ore 03:29:24