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Titolo:
DOSIMETRY OF AN IODINE-123-LABELED TROPANE TO IMAGE DOPAMINE TRANSPORTERS
Autore:
MOZLEY PD; STUBBS JB; KIM HJ; MCELGIN W; KUNG MP; MEEGALLA S; KUNG HF;
Indirizzi:
HOSP UNIV PENN,110 DONNER BLDG,3400 SPRUCE ST PHILADELPHIA PA 19104 UNIV PENN,DIV NUCL MED PHILADELPHIA PA 19104 OAK RIDGE INST SCI & EDUC OAK RIDGE TN 00000
Titolo Testata:
The Journal of nuclear medicine
fascicolo: 1, volume: 37, anno: 1996,
pagine: 151 - 159
SICI:
0161-5505(1996)37:1<151:DOAITT>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMPUTED-TOMOGRAPHY; BIODISTRIBUTION; POTENT;
Keywords:
DOSIMETRY; DOPAMINE TRANSPORTER; IODINE-123-TROPANE; SPECT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
P.D. Mozley et al., "DOSIMETRY OF AN IODINE-123-LABELED TROPANE TO IMAGE DOPAMINE TRANSPORTERS", The Journal of nuclear medicine, 37(1), 1996, pp. 151-159

Abstract

N-(3-lodopropen-2-yl)-2 beta-carbomethoxy-3 beta-(4-chlorophenl)tropane (IPT) is an analog of cocaine that selectively binds the presynaptic dopamine transporter. The present study sought to measure the radiation dosimetry of IPT in seven healthy human volunteers. Methods: Dynamic renal scans were acquired immediately after the intravenous administration of 165 +/- 16 MBq (4.45 +/- 0.42 mCi of [I-123]IPT. Between 7 and 12 sets of whole-body scans were acquired over the next 24 hr. The24-hr renal excretion fractions were measured from conjugate emissionscans of 7-11 discreet voided urine specimens. The fraction of the administered dose in 11 organs and each urine specimen was quantified from the attenuation-corrected geometric mean counts in opposing views. Subject-specific residence times were calculated for each subject independently by fitting the time-activity curves to a multicompartmental model. The radiation doses were estimated with the MIRD technique fromthe residence times for each subject individually before any results were averaged. Results: The findings showed that IPT was excreted rapidly by the renal system. There were no reservoirs of retained activityoutside the basal ganglia, where SPECT images in these subjects showed that the mean ratio of caudate to calcarine cortex averaged 25:1 at 3 hr after injection (range 19.632 hr). The basal ganglia received a radiation dose of 0.028 mGy/MBq (0.10 rad/mCi). The dose-limiting organin men was the stomach, which received an estimated 0.11 mGy/MBq (0.37 rad/mCi). In women, the critical organ was the urinary bladder at 0.14 mGy/MBq (0.51 rad/mCi). Conclusion: Relatively high-contrast imagesof the presynaptic dopamine transporters in the basal ganglia can be acquired with 185 MBq (5 mCi) of [I-123]IPT. The radiation exposure that results is significantly less than the maximum allowed by current safety guidelines for research volunteers.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 12:56:32