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Titolo:
5-HT1B RECEPTOR KNOCK OUT - BEHAVIORAL CONSEQUENCES
Autore:
RAMBOZ S; SAUDOU F; AMARA DA; BELZUNG C; SEGU L; MISSLIN R; BUHOT MC; HEN R;
Indirizzi:
COLUMBIA UNIV,CTR NEUROBIOL & BEHAV,722 W,168TH ST NEW YORK NY 10032 COLUMBIA UNIV,CTR NEUROBIOL & BEHAV NEW YORK NY 10032 CNRS,INST GENET & BIOL MOLEC & CELLULAIRE,LGME,U184 INSERM F-67404 ILLKIRCH GRAFFENS FRANCE CNRS,GDR NEUROSCI,EQUIPE MEMOIRE & RECEPTEURS SEROTONINE F-13402 MARSEILLE 20 FRANCE LAB ETHOL & PSYCHOPHYSIOL F-37200 TOURS FRANCE LAB PSYCHOPHYSIOL F-67000 STRASBOURG FRANCE
Titolo Testata:
Behavioural brain research
fascicolo: 1-2, volume: 73, anno: 1995,
pagine: 305 - 312
SICI:
0166-4328(1995)73:1-2<305:5RKO-B>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBROSPINAL-FLUID MONOAMINE; BINDING-SITES; RAT-BRAIN; SEROTONIN; AGGRESSION; AGONIST; MICE; LOCALIZATION; EXPRESSION; RU-24969;
Keywords:
ANXIETY; AGGRESSION; IMPULSIVE; LOCOMOTION; HOMOLOGOUS; RECOMBINATION; SEROTONIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
S. Ramboz et al., "5-HT1B RECEPTOR KNOCK OUT - BEHAVIORAL CONSEQUENCES", Behavioural brain research, 73(1-2), 1995, pp. 305-312

Abstract

Serotonin is a neuromodulator that is involved in a number of mood disorders such as depression, anxiety and impulsive violence. In an attempt to dissect the contribution of individual 5-HT receptor subtypes to behavior, we have generated by homologous recombination, mutant micelacking the 5-HT1B receptor. These mice did not exhibit any obvious developmental or behavioral defect. However, the hyperlocomotor effect of the 5-HT1A/1B agonist, RU 24969 was completely absent in mutant mice, indicating that this effect is mediated by 5-HT1B receptors. Moreover, when confronted with an intruder, isolated mutant mice attacked the intruder faster and more intensely than wild-type mice, suggesting an involvement of 5-HT1B receptors in the modulation of aggressive behavior. These data might be related to the fact that a class of 5-HT1 agonists, termed serenics, have anti-aggressive properties, and with thefindings that certain impulsive aggressive behaviors are associated with deficits in central serotonin.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 19:02:15