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Titolo:
SEROTONERGIC REGULATION OF ASSOCIATIVE LEARNING
Autore:
HARVEY JA;
Indirizzi:
MED COLL PENN,DEPT PHARMACOL,DIV BEHAV NEUROBIOL PHILADELPHIA PA 19129 HAHNEMANN UNIV PHILADELPHIA PA 19129
Titolo Testata:
Behavioural brain research
fascicolo: 1-2, volume: 73, anno: 1995,
pagine: 47 - 50
SICI:
0166-4328(1995)73:1-2<47:SROAL>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
LSD;
Keywords:
SEROTONIN; ASSOCIATIVE LEARNING; CLASSICAL CONDITIONING; CONDITIONED AVOIDANCE RESPONSE; 5-HT2A RECEPTORS; 5-HT2C RECEPTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
J.A. Harvey, "SEROTONERGIC REGULATION OF ASSOCIATIVE LEARNING", Behavioural brain research, 73(1-2), 1995, pp. 47-50

Abstract

This paper presents a review of studies dealing with the effects of 5-HT agonists and antagonists on learning as measured by classical conditioning of the rabbit's nictitating membrane response or the conditioned avoidance response in the rat. These studies indicate that the 5-HT2A/2C receptors are importantly involved in learning. In these behavioral paradigms,sms, enhancement of learning is only produced by drugs that are agonists at the 5-HT2A/2C receptors, and this enhancement is only blocked by drugs that are antagonists at these receptors. In addition, evidence is presented for the existence of two classes of 5-HT2A/2C antagonists consisting of negative antagonists that retard learning when given alone (ritanserin, MDL-11,939, pizotifen and cyproheptadine) and those that are neutral antagonists in that they have no effecton learning (ketanserin, mianserin, BOL and LY-53,857). However, boththe neutral and negative antagonists are equally capable of blocking the enhancement of learning produced by 5-HT2A/2C agonists. It was concluded that 5-HT2A and/or 5-HT2C agonists may provide a new approach to the treatment of learning disorders in aging or Alzheimer's disease.

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Documento generato il 19/01/20 alle ore 06:00:49