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Titolo:
A CHROMOSOME-BASED METHOD TO INFER IBD SCORES FOR MISSING AND AMBIGUOUS MARKERS
Autore:
GU C; SUAREZ BK; REICH T; TODOROV AA;
Indirizzi:
WASHINGTON UNIV,SCH MED,DEPT PSYCHIAT,BOX 8134,4940 CHILDRENS PL ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DEPT GENET ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DIV BIOSTAT ST LOUIS MO 63110
Titolo Testata:
Genetic epidemiology
fascicolo: 6, volume: 12, anno: 1995,
pagine: 871 - 876
SICI:
0741-0395(1995)12:6<871:ACMTII>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
LINKAGE;
Keywords:
IBD DISTRIBUTION; SIB-PAIR METHOD; LINKAGE ANALYSIS; MAPPING FUNCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
9
Recensione:
Indirizzi per estratti:
Citazione:
C. Gu et al., "A CHROMOSOME-BASED METHOD TO INFER IBD SCORES FOR MISSING AND AMBIGUOUS MARKERS", Genetic epidemiology, 12(6), 1995, pp. 871-876

Abstract

We propose a probability model to impute missing identical-by-descent(IBD) vectors for linkage analysis, when adjacent marker loci are typed and interference is estimable. A chromosome-based IBD distribution,conditioned on available marker data, is computed using a fast algorithm to estimate the joint probability of genes IBD at several equally spaced linked loci. Weighted IBD vectors are then used in various teststatistics for linkage analysis. As an example, we analyzed the 18 affected sib pairs in the GAW9 Problem 1 data set using Risch's led-score test. (C) 1995 Wiley-Liss, Inc.

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Documento generato il 27/09/20 alle ore 01:03:34