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Titolo:
EXPRESSION OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE MESSENGER-RNA IN RAT VASCULAR SMOOTH-MUSCLE CELLS
Autore:
TAKEDA Y; MIYAMORI I; YONEDA T; ITO Y; TAKEDA R;
Indirizzi:
KANAZAWA UNIV,SCH MED,DEPT INTERNAL MED 2,13-1 TAKARA MACHI KANAZAWA ISHIKAWA 920 JAPAN
Titolo Testata:
Life sciences
fascicolo: 4, volume: 54, anno: 1994,
pagine: 281 - 285
SICI:
0024-3205(1994)54:4<281:EO1DMI>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
MINERALOCORTICOID ACTIVITY; LIQUORICE; CLONING; AGE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
Y. Takeda et al., "EXPRESSION OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE MESSENGER-RNA IN RAT VASCULAR SMOOTH-MUSCLE CELLS", Life sciences, 54(4), 1994, pp. 281-285

Abstract

The enzyme 11beta-hydroxysteroid dehydrogenase (11-HSD) converts corticosterone to the inactive 11-dehydrocorticosterone in the rat. The bioactivity of 11-HSD, expressed as the percentage conversion of H-3-corticosterone to H-3-11-dehydrocorticosterone, was 13.7+/-0.4% in rat vascular smooth muscle cells (rVSMC). Cells treated with 100 nM dexamethasone (Dex) showed a 1.4-fold (p<0.05) increase in 11-HSD activity. Insulin (100muM) decreased 11-HSD activity by 0.8-fold (p<0.05). Expression of 11-HSD mRNA was also confirmed in rVSMC by Northern blot analysis. Dexamethasone increased and insulin decreased the levels of 11-HSDmRNA in parallel with the increase in bioactivity. Vascular smooth muscle cells express 11-HSD activity; the access of corticosterone to vascular smooth muscle receptors may be modulated by the enzyme.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 16:22:12