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Titolo:
OVEREXPRESSION OF THE SKY RECEPTOR TYROSINE KINASE AT THE CELL-SURFACE OR IN THE CYTOPLASM RESULTS IN LIGAND-INDEPENDENT ACTIVATION
Autore:
TAYLOR ICA; ROY S; VARMUS HE;
Indirizzi:
NCI BETHESDA MD 20892 NCI BETHESDA MD 20892
Titolo Testata:
Oncogene
fascicolo: 12, volume: 11, anno: 1995,
pagine: 2619 - 2626
SICI:
0950-9232(1995)11:12<2619:OOTSRT>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN; ONCOGENE;
Keywords:
SKY RECEPTOR TYROSINE KINASE; DIMERIZATION; ISOFORMS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
I.C.A. Taylor et al., "OVEREXPRESSION OF THE SKY RECEPTOR TYROSINE KINASE AT THE CELL-SURFACE OR IN THE CYTOPLASM RESULTS IN LIGAND-INDEPENDENT ACTIVATION", Oncogene, 11(12), 1995, pp. 2619-2626

Abstract

Most receptor tyrosine kinases are activated by dimerization induced by their cognate ligands, Protein S, an abundant serum protein previously shown to be a potent anticoagulation factor, has been proposed to be a ligand for the Sky tyrosine kinase (Stitt et al., 1995), Here we show that Sky, when expressed to high levels, is tyrosine phosphorylated even in the absence of a ligand, Furthermore, a version of Sky (termed Sky Delta SS) engineered to be overexpressed in the cytoplasm and thus in a ligand-free environment, can function as a dimeric tyrosine kinase, Sky Delta SS can transform RatB1a fibroblasts and thus retainsall the properties of the full-length Sky kinase, These data suggest that Sky, when overexpressed either at the cell surface or in the cytoplasm, is competent to form dimers even in the absence of its ligand. We also demonstrate that an isoform of Sky, originally reported as Brtand here termed Sky Isoform I, resides in the cytoplasm, Therefore, the activities of Sky Delta SS we describe may reflect those of the naturally occurring Isoform I.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 20:23:42