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Titolo:
EFFECTS OF 6R-L-ERYTHRO-5,6,7,8-TETRAHYDROBIOPTERIN ON THE DOPAMINERGIC AND CHOLINERGIC RECEPTORS AS EVALUATED BY POSITRON EMISSION TOMOGRAPHY IN THE RHESUS-MONKEY
Autore:
TANI Y; ISHIHARA T; KANAI T; OHNO T; ANDERSSON J; LILJA A; ANTONI G; FASTH KJ; BJURLING P; WESTERBERG G; HARTVIG P; ONOE H; WATANABE Y; LANGSTROM B;
Indirizzi:
OSAKA BIOSCI INST,DEPT NEUROSCI,6-2-4 FURUEDAI SUITA OSAKA 565 JAPAN OSAKA BIOSCI INST,DEPT NEUROSCI SUITA OSAKA 565 JAPAN SUNTORY INST BIOMED RES OSAKA JAPAN UPPSALA UNIV,PET CTR UPPSALA SWEDEN
Titolo Testata:
Journal of neural transmission
fascicolo: 3, volume: 102, anno: 1995,
pagine: 189 - 208
SICI:
0300-9564(1995)102:3<189:EO6OTD>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-BRAIN; RAT-BRAIN; ACETYLCHOLINE-RELEASE; SEROTONIN RECEPTORS; PARKINSONS-DISEASE; PASSIVE-AVOIDANCE; INVITRO BINDING; TETRAHYDROBIOPTERIN; PET; ENHANCEMENT;
Keywords:
TETRAHYDROBIOPTERIN; MUSCARINIC CHOLINERGIC RECEPTOR; DOPAMINE D-1, D-2, D-3 RECEPTORS; POSITRON EMISSION TOMOGRAPHY; MONKEY BRAIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
59
Recensione:
Indirizzi per estratti:
Citazione:
Y. Tani et al., "EFFECTS OF 6R-L-ERYTHRO-5,6,7,8-TETRAHYDROBIOPTERIN ON THE DOPAMINERGIC AND CHOLINERGIC RECEPTORS AS EVALUATED BY POSITRON EMISSION TOMOGRAPHY IN THE RHESUS-MONKEY", Journal of neural transmission, 102(3), 1995, pp. 189-208

Abstract

The effects of 6R-L-erythro-5,6,7,8-tetrahydrobiopterin (R-THBP) on the central cholinergic and dopaminergic systems in the Rhesus monkey brain were investigated by positron emission tomography (PET) with the muscarinic cholinergic receptor ligands (N-[C-11]methyl-benztropine) and dopaminergic receptor ligands selective for D-1, D-2, and D-3 subtypes ([C-11]SCH23390, N-[C-11]methyl-spiperone, and (+)[C-11]UH232, respectively). None of the doses (3, 10, and 30 mg/kg i.v.) of R-THBP used significantly affected the regional cerebral blood flow (rCBF as determined by Raichle's (H2O)-O-15 method), and 10 mg/kg of R-THBP had little effect on the regional cerebral metabolic rate of glucose (rCMRglc) in the Rhesus monkey brain, as assessed by the graphical [F-18]fluoro-deoxyglucose method. The effect of R-THBP on the muscarinic cholinergic system was dose dependent; while 3 mg/kg of R-THBP did not significantly alter the uptake ratio of N-[C-11]methyl-benztropine in several brain regions to that in the cerebellum, 10 and 30 mg/kg of R-THBP significantly reduced the uptake ratio in the thalamus, as well as in the frontal and temporal cortices. None of the doses (3, 10, and 30 mg/kg i.v.) of R-THBP tested affected [C-11]SCH23390 (dopamine D-1 receptor) binding. However, the k3 value for N-[C-11]methyl-spiperone (dopamine D-2 receptor) binding, which represents the association rate x B-max value, was significantly decreased in the striatum. The uptake ratio of (+)[C-11]UH232 (dopamine D-3 receptor) in the striatum to that inthe cerebellum was also decreased by administration of R-THBP (3 and 30 mg/kg i.v.). These findings suggest that R-THBP acts on dopamine D-2 and D-3 receptors selectively without markedly affecting dopamine D-1 receptor binding. Furthermore, the changes in cholinergic and dopamine D-2 and D-3 receptors in vivo can not be attributed to a change in rCBF but may depend on the action of R-THBP.

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Documento generato il 19/01/20 alle ore 14:30:57