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Titolo:
YY1 AND SP1 TRANSCRIPTION FACTORS BIND THE HUMAN TRANSFERRIN GENE IN AN AGE-RELATED MANNER
Autore:
ADRIAN GS; SETO E; FISCHBACH KS; RIVERA EV; ADRIAN EK; HERBERT DC; WALTER CA; WEAKER FJ; BOWMAN BH;
Indirizzi:
UNIV TEXAS,HLTH SCI CTR,DEPT CELLULAR & STRUCT BIOL,7703 FLOYD CURL DR SAN ANTONIO TX 78284 UNIV TEXAS,HLTH SCI CTR,INST BIOTECHNOL SAN ANTONIO TX 78284 UNIV TEXAS,HLTH SCI CTR,DEPT PATHOL SAN ANTONIO TX 78284
Titolo Testata:
The journals of gerontology. Series A, Biological sciences and medical sciences
fascicolo: 1, volume: 51, anno: 1996,
pagine: 66 - 75
SICI:
1079-5006(1996)51:1<66:YASTFB>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
TISSUE-SPECIFIC EXPRESSION; TRANSGENIC MICE; IRON-DEFICIENCY; C-MYC; PROTEIN; MOUSE; PROMOTERS; REPRESSOR; VALUES; DELTA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
G.S. Adrian et al., "YY1 AND SP1 TRANSCRIPTION FACTORS BIND THE HUMAN TRANSFERRIN GENE IN AN AGE-RELATED MANNER", The journals of gerontology. Series A, Biological sciences and medical sciences, 51(1), 1996, pp. 66-75

Abstract

The iron-binding protein transferrin has major roles in transporting,delivering, and sequestering ferric ions acquired by body tissues. Yet, during aging, serum transferrin levels decrease in humans. Likewise, in transgenic mice carrying chimeric human transferrin transgenes, liver expression of transferrin transgenes decreases with age. The aging regulation is due to decreased gene transcription. Electrophoretic mobility shift assays and antibody-recognition have revealed the binding of 5' regulatory elements of the human transferrin gene by three YY1proteins, called YY1, YY1-a, and YY1-b, and an Sp1-a transcription factor. An age-related increase in YY1-a and YY1-b binding activities and a decrease in Sp1-like binding activity were shown. Since Sp1 is a positive transcription factor and YY1 can be a negative transcription factor, the alterations in their binding with age could cause the decreased transcription of the human transferrin transgene, and also the age-related decreased serum transferrin levels in humans.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 14:33:07