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Titolo:
EVIDENCE FOR THE INVOLVEMENT OF THE WNT-2 GENE IN HUMAN COLORECTAL-CANCER
Autore:
VIDER BZ; ZIMBER A; CHASTRE E; PREVOT S; GESPACH C; ESTLEIN D; WOLLOCH Y; TRONICK SR; GAZIT A; YANIV A;
Indirizzi:
TEL AVIV UNIV,SACKLER SCH MED,DEPT HUMAN MICROBIOL IL-69978 TEL AVIV ISRAEL TEL AVIV UNIV,SACKLER SCH MED,DEPT HUMAN MICROBIOL IL-69978 TEL AVIV ISRAEL HEBREW UNIV JERUSALEM,DEPT ANIM SCI IL-76100 REHOVOT ISRAEL HOSP ST ANTOINE,INSERM,U55,EQUIPE CANCEROGENESE & DIFFERENCIAT EPITHELIUM GA F-75571 PARIS 12 FRANCE HASHARON HOSP,DEPT SURG B PETAH TIQWA ISRAEL SANTA CRUZ BIOTECHNOL SANTA CRUZ CA 95060
Titolo Testata:
Oncogene
fascicolo: 1, volume: 12, anno: 1996,
pagine: 153 - 158
SICI:
0950-9232(1996)12:1<153:EFTIOT>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAMMARY ONCOGENE INT-1; WINGLESS PROTEIN; DEVELOPMENTAL REGULATORS; PROVIRAL ACTIVATION; CELL-LINE; EXPRESSION; XENOPUS; EMBRYOS; TRANSFORMATION; FAMILY;
Keywords:
WNT GENES; COLORECTAL CANCER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
62
Recensione:
Indirizzi per estratti:
Citazione:
B.Z. Vider et al., "EVIDENCE FOR THE INVOLVEMENT OF THE WNT-2 GENE IN HUMAN COLORECTAL-CANCER", Oncogene, 12(1), 1996, pp. 153-158

Abstract

Colorectal cancer (CRC) is onte of the most frequent cancers in humans. It develops via a multistage process involving alterations of both protooncogenes and tumor suppressor genes. In the present report we determined the level of expression of several Wnt genes in CRC by RT-PCRand direct sequencing. While Wnt-1 was not detectably expressed in any colonic tissues, Wnt-5a gene was efficiently expressed both in nontumorous as well as in colonic tumor tissues. In contrast, the Wnt-2 gene, which was expressed at low levels in normal colon, exhibited overexpression in all tumor tissue samples at the different Dukes' stages ofCRC progression, including premalignant polyps and liver metastases. Overexpression of the Wnt-2 gene occurred also in other digestive neoplasms such as gastric and esophageal carcinomas, as well as in diverticulitis associated with stenosis or pseudo-tumor.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 22:34:12