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Titolo:
THE FIRST EXON OF AD12 E1A EXCLUDING THE TRANSACTIVATION DOMAIN MEDIATES DIFFERENTIAL BINDING OF COUP-TF AND NF-KAPPA-B TO THE MHC CLASS-I ENHANCER IN TRANSFORMED-CELLS
Autore:
KUSHNER DB; PEREIRA DS; LIU XH; GRAHAM FL; RICCIARDI RP;
Indirizzi:
UNIV PENN,SCH DENT MED,DEPT MICROBIOL,4010 LOCUST ST PHILADELPHIA PA 19104 UNIV PENN,SCH DENT MED,DEPT MICROBIOL PHILADELPHIA PA 19104 UNIV PENN,GRAD GRP MOLEC BIOL PHILADELPHIA PA 19104 MCMASTER UNIV,DEPT BIOL HAMILTON ON L8S 4K1 CANADA MCMASTER UNIV,DEPT PATHOL HAMILTON ON L8S 4K1 CANADA
Titolo Testata:
Oncogene
fascicolo: 1, volume: 12, anno: 1996,
pagine: 143 - 151
SICI:
0950-9232(1996)12:1<143:TFEOAE>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
DNA-BINDING; RAT-CELLS; GENE-EXPRESSION; P65 SUBUNIT; TRANSCRIPTION FACTORS; REL ONCOGENE; ADENOVIRUS-TYPE-12; PROTEINS; P50; REPRESSION;
Keywords:
ADENOVIRUS; E1A; COUP-TF; NF-KAPPA-B;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
53
Recensione:
Indirizzi per estratti:
Citazione:
D.B. Kushner et al., "THE FIRST EXON OF AD12 E1A EXCLUDING THE TRANSACTIVATION DOMAIN MEDIATES DIFFERENTIAL BINDING OF COUP-TF AND NF-KAPPA-B TO THE MHC CLASS-I ENHANCER IN TRANSFORMED-CELLS", Oncogene, 12(1), 1996, pp. 143-151

Abstract

The major histocompatibility complex class I enhancer is the target for adenovirus-12 E1A-mediated down-regulation of class I transcription. In Ad12 transformed rodent cells, the class I enhancer is down-regulated through increased binding of the repressor COUP-TF to the R2 element and decreased binding of the activator NF-kappa B (p50/p65) to theR1 element. The reduced surface levels of class I antigens contributeto the tumorigenic potential of Ad12 transformed cells by favoring their immunoescape from cytotoxic T-lymphocytes. Previous studies using transformed containing hybrid Ad5/Ad12 E1A (plus Ad12 E1B) genes have indicated that sequences within the first exon of the 266R Ad12 E1A gene are required for class I down-regulation and tumorigenesis. In thisstudy we demonstrate that these same sequences, which exclude the Ad12 CR3 transactivation domain, are also required for increased COUP-TF binding to the R2 element and decreased NF-kappa B binding to the R1 element of the class I enhancer. We further show that diminished NF-kappa B binding is not due to a lack of NF-kappa B1-p50 in the nuclei of Ad12 transformed rat cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 10:21:36