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Titolo:
OXIDANT-ANTIOXIDANT BALANCE IN GRANULOCYTES DURING ARDS - EFFECT OF N-ACETYLCYSTEINE
Autore:
LAURENT T; MARKERT M; FEIHL F; SCHALLER MD; PERRET C;
Indirizzi:
CHU VAUDOIS,DEPT MED,INTENS CARE UNIT,BH-10 CH-1011 LAUSANNE SWITZERLAND CHU VAUDOIS,INST PHYSIOPATHOL CLIN CH-1011 LAUSANNE SWITZERLAND CHU VAUDOIS,CENT LAB CLIN CHIM CH-1011 LAUSANNE SWITZERLAND CHU VAUDOIS,SERV SOINS INTENSIFS MED CH-1011 LAUSANNE SWITZERLAND
Titolo Testata:
Chest
fascicolo: 1, volume: 109, anno: 1996,
pagine: 163 - 166
SICI:
0012-3692(1996)109:1<163:OBIGDA>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY-DISTRESS SYNDROME; ALPHA-1-PROTEINASE INHIBITOR; NEUTROPHILS; GLUTATHIONE; CYSTEINE;
Keywords:
ACETYLCYSTEINE; ANTIOXIDANTS; FREE RADICALS; GLUTATHIONE; GRANULOCYTES; RESPIRATORY DISTRESS SYNDROME, ADULT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
T. Laurent et al., "OXIDANT-ANTIOXIDANT BALANCE IN GRANULOCYTES DURING ARDS - EFFECT OF N-ACETYLCYSTEINE", Chest, 109(1), 1996, pp. 163-166

Abstract

The production of cytotoxic oxygen radicals by activated granulocytesis a proposed mechanism of lung injury in ARDS. Protective effects ofN-acetylcysteine (NAG) have been described in experimental and clinical ARDS, NAC could act in part by replenishing the intracellular stores of glutathione (GSH) in activated granulocytes, leading to detoxification of oxygen radicals produced by these cells, To test this hypothesis, 16 patients in the early phase of ARDS were randomized to receiveeither NAC (n=8) or placebo (n=8); granulocyte GSH, granulocyte oxygen radical production, and plasma levels of granulocyte elastase were measured in blood samples drawn sequentially within 8 h after the onsetof ARDS (day 0), and then 24 (day 1), 72 (day 3), and 120 h (day 5) after the first sample; treatment with NAC or placebo was started immediately after day 0 and stopped just after day 3. Granulocyte GSH was significantly higher on days 1 and 3 when NAC was received by the patient. Unstimulated oxygen radical production, as measured ex vivo by luminol- and lucigenin-amplified chemiluminescence (CL), was higher in granulocytes from ARDS patients than from healthy control subjects, but was not influenced by NAG. The plasma levels of granulocyte elastase were five to eight times above the upper normal limit on day 0, decreased steadily until day 5, and were uninfluenced by NAC. In summary, parenteral NAC treatment started within 8 h of diagnosis increases the intracellular GSH in the granulocytes of ARDS patients without decreasing spontaneous oxidant production by these cells, The mechanisms of theprotective effects of this drug previously reported in experimental and clinical ARDS remain to be extablished.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 07:18:26