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Titolo:
QUANTITATIVE CT PREDICTS THE SEVERITY OF PHYSIOLOGICAL DYSFUNCTION INPATIENTS WITH LYMPHANGIOLEIOMYOMATOSIS
Autore:
CRAUSMAN RS; LYNCH DA; MORTENSON RL; KING TE; IRVIN CG; HALE VAE; NEWELL JD;
Indirizzi:
NATL JEWISH CTR IMMUNOL & RESP MED,DEPT MED,DIV PULM,1400 JACKSON ST DENVER CO 80206 NATL JEWISH CTR IMMUNOL & RESP MED,DEPT MED,DIV PULM DENVER CO 80206 UNIV COLORADO,CTR HLTH SCI,DEPT MED BOULDER CO 80309 UNIV COLORADO,CTR HLTH SCI,DEPT RADIOL BOULDER CO 80309 NATL JEWISH CTR IMMUNOL & RESP MED,DEPT RADIOL DENVER CO 80206
Titolo Testata:
Chest
fascicolo: 1, volume: 109, anno: 1996,
pagine: 131 - 137
SICI:
0012-3692(1996)109:1<131:QCPTSO>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH-RESOLUTION CT; PULMONARY-FUNCTION TESTS; AIR-FLOW LIMITATION; COMPUTED-TOMOGRAPHY; DIFFUSING-CAPACITY; LUNG DENSITY; EMPHYSEMA; LYMPHANGIOMYOMATOSIS; DISEASE; CHEST;
Keywords:
COMPUTED TOMOGRAPHY; EXERCISE PHYSIOLOGY; PULMONARY LYMPHANGIOLEIOMYOMATOSIS (LAM); PULMONARY MECHANICS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
R.S. Crausman et al., "QUANTITATIVE CT PREDICTS THE SEVERITY OF PHYSIOLOGICAL DYSFUNCTION INPATIENTS WITH LYMPHANGIOLEIOMYOMATOSIS", Chest, 109(1), 1996, pp. 131-137

Abstract

Purpose: To assess quantitative high-resolution CT (quantitative CT) as a diagnostic and prognostic tool in pulmonary lymphangioleiomyomatosis. Methods: Spirometry, lung volumes, diffusing capacity, exercise physiology, and expiratory high-resolution CT (HRCT) examinations were performed on a cohort of ten patients with the diagnosis of lymphangioleiomyomatosis (LAM) referred to a tertiary care center. HRCT examinations were also done on ten normal control subjects. A thresholding technique was used to quantitatively assess the amount of abnormal cysticparenchyma present on each of the two images obtained for each subject with LAM and for each normal control subject. This numeric index of cystic parenchyma, the quantitative CT index, was then examined (1) asa diagnostic measure to distinguish the subjects with LAM from the normal control subjects and (2) as a prognostic measure to assess disease severity in the subjects with LAM. Linear regression of the quantitative CT index against physiologic indexes of pulmonary function and exercise performance was analyzed to determine the relationship between this radiologic assessment of disease severity and functional impairment. Results: The quantitative CT index was significantly greater for the LAM patients, 37.2+/-6.9 (SEM), compared with the control group, 0.8+/-0.2 (p=0.0001). Linear regression analysis demonstrated significant linear correlation between the quantitative CT index and measures ofairflow (FEV(1), r=-0.90, p=0.0005), air trapping (residual volume, r=0.70, p=0.02), diffusing capacity (diffusing capacity for carbon monoxide, r=-0.76, p=0.01), gas exchange (alveolar to arterial oxygen gradient) at rest, r=0.69, p=0.007, and at maximum exercise, r=0.79, p=0.007) and exercise performance (maximum workload, r=-0.84, p=0.002), andoxygen utilization (oxygen utilization at maximum exercise, r=-0.76, p=0.01). Conclusion: Quantitative CT techniques can distinguish subjects with LAM from normal controls. Further, the quantitative CT index correlates well with physiologic measurements of airflow, lung volumes,diffusing capacity, and exercise performance and, thus, may provide auseful measure of disease severity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 07:29:24