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Titolo:
EXPRESSION AND LONG-TERM PROGNOSTIC VALUE OF CD34 IN CHILDHOOD AND ADULT ACUTE LYMPHOBLASTIC-LEUKEMIA
Autore:
VANHAEKE DR; BENE MC; GARAND R; FAURE GC; GARDAIS J; LEGLISE MC; LECALVEZ G; BERNIER M; MASSY M; GRIVEAU AM; BROUTARD P; LEBRUN C; BONHOMME J; CHASSAGNE B; DEMEOCQ F; RAPATEL C; TAVERNIER F; JOUAULT H; LELONG F; CHRETIEN P; SOLARY E; CASASNOVAS RO; MAYNADIE M; BENSA JC; FAVRE M; JACOB MC; SARTIAUX C; HUART JL; DROUET M; PRALORAN V; TRIMOREAU F; CAMPOS L; LARESE A; PONCELET P; BESSONFAURE I; BRUNET C; LAVABREBERTRAND T; TAIB J; KANDEL G; JUNG G; HARROUSSEAU JL; PHILIP P; MONPOUX F; BAUDOUIN F; SUDAKA I; CALDANI C; VANHAEKE D; BERNARD A; VALENSI F; BOURIN P; ARBORIO M; SCHAISON G; BOUMSELL L; ADAM M; DOUAI L; BRIZARD A; DALIPHARD S; GENETET N; FAUCHET R; DRENOU B; LEES O; LENORMAND B; VANNIER JP; SABIDO O; GUYOTAT D; VASSELON C; FALKENRODT A; ALBERT A; BREMOND JL; GEORGET MT; KUHLEIN E; LEBARON F; DUTHILLEUL P; REUMAUX F; FAURE G; KOLOPPSARDA MN; BORDIGONI P; WITZ F; BAYLE C; ANTONINI J; CHARPENTIER A;
Indirizzi:
FAC MED,IMMUNOL LAB,BP 184 F-54500 VANDOEUVRE NANCY FRANCE HOP CIMIEZ,HEMATOL LAB F-06003 NICE FRANCE
Titolo Testata:
Leukemia & lymphoma
fascicolo: 1-2, volume: 20, anno: 1995,
pagine: 137 - 142
SICI:
1042-8194(1995)20:1-2<137:EALPVO>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLONY-FORMING CELLS; MARROW-CELLS; BONE-MARROW; FEATURES; PRECURSORS; ANTIGENS;
Keywords:
ACUTE LYMPHOBLASTIC LEUKEMIA; CD34; OUTCOME;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
D.R. Vanhaeke et al., "EXPRESSION AND LONG-TERM PROGNOSTIC VALUE OF CD34 IN CHILDHOOD AND ADULT ACUTE LYMPHOBLASTIC-LEUKEMIA", Leukemia & lymphoma, 20(1-2), 1995, pp. 137-142

Abstract

Clinical and laboratory characteristics at diagnosis, and long-term. (up to 7 years) evolution, were analysed in 156 patients (66 adults and 90 children) with acute lymphoblastic leukemia (ALL), according to the expression of CD34. Eighty-three patients had CD34+ and 73 patientsCD34- blasts at diagnosis. In adults, CD34+ ALL was more often of B-lineage (p = .003). White blood cell counts were higher both in children with CD34- B-lineage ALL (p = .02) and adults with CD34- T-lineage ALL (p = .05). Adult patients with CD34- T-lineage ALL were older (p = .04) and had more frequent splenic or liver enlargement (p = .02). Children with CD34+ ALL had a significantly (p = .04) longer event-free follow-up than CD34- children. Survival curves showed that after induction of remission, relapses were less frequent during the first 2 yearsfor patients with CD34+ B-lineage ALL. After 2 years, however, event-free survival curves of CD34+ and CD34- patients merged. Thus it seemsthat CD34+ has no significant benefit for ALL patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 14:31:49