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Titolo:
AN AMINO-ACID POLYMORPHISM IN HISTIDINE-RICH GLYCOPROTEIN (HRG) EXPLAINS 59-PERCENT OF THE VARIANCE IN PLASMA HRG LEVELS
Autore:
HENNIS BC; BOOMSMA DI; VANBOHEEMEN PA; ENGESSER L; KIEVIT P; DOOIJEWAARD G; KLUFT C;
Indirizzi:
TNO,GAUBIUS INST,PG,BOX 2215 2301 CE LEIDEN NETHERLANDS FREE UNIV AMSTERDAM,DEPT PSYCHON AMSTERDAM NETHERLANDS
Titolo Testata:
Thrombosis and haemostasis
fascicolo: 6, volume: 74, anno: 1995,
pagine: 1497 - 1500
SICI:
0340-6245(1995)74:6<1497:AAPIHG>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
PEDIGREE ANALYSIS; PLASMINOGEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
B.C. Hennis et al., "AN AMINO-ACID POLYMORPHISM IN HISTIDINE-RICH GLYCOPROTEIN (HRG) EXPLAINS 59-PERCENT OF THE VARIANCE IN PLASMA HRG LEVELS", Thrombosis and haemostasis, 74(6), 1995, pp. 1497-1500

Abstract

A pedigree-based maximum likelihood method developed by Lange et al. (12) was used to study the contribution of a newly defined di-allelic polymorphism in histidine-rich glycoprotein (HRG) to the plasma levelsof HRG. In four families (n = 99) and 20 volunteers we found a heritability of 70%, an age effect of 3% and an effect of individual environmental factors of 27%, These results are remarkably similar to the results found in a previous parent-twin study in which a heritability of 69% and an effect of random environment of 31% was found. The overall genetic influence in the present study can be subdivided into an effect of 59% by the HRG phenotype and 11% by residual genetic factors. Theinfluence of the HRG phenotype of 59% can entirely be explained by adding up the effect of the two alleles that make up the phenotype. These results indicate a codominant inheritance pattern of HRG levels in which the genetic influence can almost completely be ascribed to the additive effect of the di-allelic HRG locus whereas only a small part isdue to other loci.

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Documento generato il 19/01/20 alle ore 09:22:41