Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
LP(A) LEVELS AND ATHEROSCLEROTIC VASCULAR-DISEASE IN A SAMPLE OF PATIENTS WITH FAMILIAL HYPERCHOLESTEROLEMIA SHARING THE SAME GENE DEFECT
Autore:
CARMENA R; LUSSIERCACAN S; ROY M; MINNICH A; LINGENHEL A; KRONENBERG F; DAVIGNON J;
Indirizzi:
CLIN RES INST MONTREAL,HYPERLIPIDEMIA & ATHEROSCLEROSIS RES GRP,110 PINE AVE W MONTREAL PQ H2W 1R7 CANADA CLIN RES INST MONTREAL,HYPERLIPIDEMIA & ATHEROSCLEROSIS RES GRP MONTREAL PQ H2W 1R7 CANADA UNIV VALENCIA,HOSP CLIN,ENDOCRINE SERV E-46100 VALENCIA SPAIN INNSBRUCK UNIV,INST MED BIOL & GENET A-6020 INNSBRUCK AUSTRIA
Titolo Testata:
Arteriosclerosis, thrombosis, and vascular biology
fascicolo: 1, volume: 16, anno: 1996,
pagine: 129 - 136
SICI:
1079-5642(1996)16:1<129:LLAAVI>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY DISEASE; DENSITY-LIPOPROTEIN RECEPTOR; HEART-DISEASE; MYOCARDIAL-INFARCTION; APOLIPOPROTEIN-B; RISK FACTOR; SERUM LIPOPROTEIN(A); PLASMA; POPULATIONS; PHENOTYPE;
Keywords:
FAMILIAL HYPERCHOLESTEROLEMIA; LIPOPROTEIN(A); ATHEROSCLEROTIC COMPLICATIONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
55
Recensione:
Indirizzi per estratti:
Citazione:
R. Carmena et al., "LP(A) LEVELS AND ATHEROSCLEROTIC VASCULAR-DISEASE IN A SAMPLE OF PATIENTS WITH FAMILIAL HYPERCHOLESTEROLEMIA SHARING THE SAME GENE DEFECT", Arteriosclerosis, thrombosis, and vascular biology, 16(1), 1996, pp. 129-136

Abstract

There is considerable variation in the severity of cardiovascular disease among patients with familiar hypercholesterolemia (FH). Some reports have suggested that plasma lipoprotein(a) [Lp(a)] levels may explain such variation and that FH subjects deficient in LDL receptors, especially those with coronary heart disease, tend to have elevated Lp(a)levels. We have investigated the possible role of the LDL receptor indetermining plasma Lp(a) levels in a genetically homogeneous FH population and the contribution of Lp(a) to cardiovascular risk. A total of98 FH subjects and 66 healthy first- and second-degree relatives from30 families with FH due to the French-Canadian >10-kilobase deletion of the LDL receptor gene were studied. A reference group of 392 normolipidemic French-Canadian participants in a Heart Health Survey was used for comparison. FH subjects were subdivided into subsets of 63 individuals free from atherosclerotic vascular disease (AVD) and 35 individuals with AVD. A complete cardiovascular evaluation was performed, andplasma lipid, lipoprotein, and Lp(a) levels were measured in all subjects in the absence of medication. Apolipoprotein (a) [apo(a)] phenotype was deter-mined in 112 of FH and non-FH subjects. The log-transformed values for plasma Lp(a) were not significantly different among the three groups: 0.98 +/- 0.54 (mean +/- SD) in FH subjects with AVD, 0.89 +/- 0.51 in FH subjects without AVD, and 0.82 +/- 0.64 in their relatives. The distribution of the apo(a) phenotypes did not differ between the FH and non-FH groups. Comparison of two age- and sex-matched subgroups of FH subjects, with and without AVD, failed to show any differences in Lp(a) level. However, mean Lp(a) log values in the reference group (n=392) were significantly lower than values obtained for the total FH group (0.79 +/- 0.57 versus 0.92 +/- 0.52, respectively; P<.05)but were not different from those of the unaffected family members. Thus, in our sample, the LDL receptor appears not to influence plasma Lp(a) levels; rather, these levels reflect shared apo(a) genes. The cardiovascular risk in this group of subjects with FH was related to age,male sex, total and LDL cholesterol, and higher apoB but not Lp(a) levels.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 15:35:51