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Titolo:
HYPOGLYCEMIA PREVENTS INCREASE IN LACTIC-ACIDOSIS DURING REPERFUSION AFTER TEMPORARY CEREBRAL-ISCHEMIA IN RATS
Autore:
SAPPEYMARINIER D; CHILEUITT L; WEINER MW; FADEN AI; WEINSTEIN PR;
Indirizzi:
EDITORIAL OFF,DEPT NEUROL SURG,1360 9TH AVE,SUITE 210 SAN FRANCISCO CA 94122 VET ADM MED CTR,MAGNET RESONANCE UNIT SAN FRANCISCO CA 94121 UNIV CALIF SAN FRANCISCO,SCH MED,DEPT MED SAN FRANCISCO CA 94143 UNIV CALIF SAN FRANCISCO,SCH MED,DEPT RADIOL SAN FRANCISCO CA 94143 UNIV CALIF SAN FRANCISCO,SCH MED,DEPT NEUROL SAN FRANCISCO CA 94143 UNIV CALIF SAN FRANCISCO,SCH MED,DEPT NEUROL SURG SAN FRANCISCO CA 94143
Titolo Testata:
NMR in biomedicine
fascicolo: 4, volume: 8, anno: 1995,
pagine: 171 - 178
SICI:
0952-3480(1995)8:4<171:HPIILD>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAGNETIC-RESONANCE SPECTROSCOPY; BRAIN ENERGY-METABOLISM; FREE MAGNESIUM CONCENTRATION; INTRACELLULAR FREE MG-2+; P-31 NMR-SPECTROSCOPY; HYPERGLYCEMIC RATS; BLOOD-FLOW; LIQUID-CHROMATOGRAPHY; INSULIN; INJURY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
D. Sappeymarinier et al., "HYPOGLYCEMIA PREVENTS INCREASE IN LACTIC-ACIDOSIS DURING REPERFUSION AFTER TEMPORARY CEREBRAL-ISCHEMIA IN RATS", NMR in biomedicine, 8(4), 1995, pp. 171-178

Abstract

Sequential P-31 and H-1 MRS was used to measure cerebral phosphate metabolites, intracellular pH, and lactate in normoglycemic and hypoglycemic rats during 30 min of complete cerebral ischemia and 5.5 h of reperfusion. These results were correlated with brain levels of free fatty acids (FFAs), excitatory amino acids, cations, and water content at death, The lactate/N-acetyl aspartate ratio was not significantly different between groups before or during occlusion. During reperfusion, the ratio was higher in normoglycemic rats from 3 to 85 min (p less than or equal to 0.05), and recovery time was faster in hypoglycemic rats(29 vs 45 min; p=0.04), suggesting reduced lactate production and faster recovery of aerobic metabolism, During occlusion, significant but comparable decrease of intracellular pH occurred in each group. Intracellular pH was higher in hypoglycemic rats at 140 min and 260 min of reperfusion, Water content, Na and K+ concentrations, and FFA and excitatory amino acid levels were not significantly different between groups, but hypoglycemic rats had less depletion of levels of Mg2+ (p=0.011). These results show that hypoglycemia has a limited but potentially beneficial effect on postischemic lactic acidosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 19:26:24