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Titolo:
LACTATE-DEHYDROGENASE ACTIVITY AND ISOFORM DISTRIBUTION IN THE RAT PELVIC GANGLION - EFFECTS OF DIABETES AND BLADDER OUTLET OBSTRUCTION
Autore:
BERGGREN T; ARNER A; UVELIUS B;
Indirizzi:
UNIV LUND HOSP,DEPT UROL S-22185 LUND SWEDEN LUND UNIV,DEPT PHYSIOL & BIOPHYS S-22362 LUND SWEDEN
Titolo Testata:
Urological research
fascicolo: 6, volume: 23, anno: 1995,
pagine: 395 - 399
SICI:
0300-5623(1995)23:6<395:LAAIDI>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYPERTROPHIC SMOOTH-MUSCLE; URINARY-BLADDER; PERIPHERAL-NERVE; NEURONS; METABOLISM;
Keywords:
RAT; PELVIC GANGLION; LACTATE DEHYDROGENASE; ISOFORMS; INFRAVESICAL; OBSTRUCTION DIABETES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
T. Berggren et al., "LACTATE-DEHYDROGENASE ACTIVITY AND ISOFORM DISTRIBUTION IN THE RAT PELVIC GANGLION - EFFECTS OF DIABETES AND BLADDER OUTLET OBSTRUCTION", Urological research, 23(6), 1995, pp. 395-399

Abstract

We have previously shown that the intramural motor nerves in the rat bladder can function in anoxic conditions. The present study aims to explore the distribution and activity of lactate dehydrogenase (LDH), the key enzyme for ATP generation in anoxia. The activity and isoform distribution pattern of LDH was studied in pelvic ganglia from male andfemale rats. A histochemical investigation showed that the LDH activity was intense in the ganglion cells, and weak in the other tissue components (nerve bundles, connective tissue). The male pelvic ganglion weighed 55% more than the female pelvic ganglion, the enzyme activity per unit ganglion weight was 60% higher and the total LDH activity was 155% higher. The isoform distribution was similar, with M4 being dominant isoform, followed by M3H. Infravesical outlet obstruction in the female rat induced a threefold increase in ganglion weight, and the total LDH activity increased twofold. In this hypertrophic female ganglion a decreased relative amount of M4, and an increased amount of MH3, was found. Diabetes in the male rat had no effect on ganglion weight orits contents and isoform distribution of LDH.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 00:25:22