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Titolo:
NATURALLY-OCCURRING SIN-NOMBRE VIRUS GENETIC REASSORTANTS
Autore:
HENDERSON WW; MONROE MC; JEOR SCS; THAYER WP; ROWE JE; PETERS CJ; NICHOL ST;
Indirizzi:
CTR DIS CONTROL & PREVENT,DIV VIRAL & RICKETTSIAL DIS,SPECIAL PATHOGENS BRANCH,G-14 ATLANTA GA 30333 CTR DIS CONTROL & PREVENT,DIV VIRAL & RICKETTSIAL DIS,SPECIAL PATHOGENS BRANCH ATLANTA GA 30333 UNIV NEVADA,DEPT MICROBIOL RENO NV 89557 EMORY UNIV,DEPT MICROBIOL & IMMUNOL ATLANTA GA 30322
Titolo Testata:
Virology
fascicolo: 2, volume: 214, anno: 1995,
pagine: 602 - 610
SICI:
0042-6822(1995)214:2<602:NSVGR>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROSPECT-HILL VIRUS; NUCLEOTIDE-SEQUENCE ANALYSIS; STRAIN HALLNAS B1; GENOME SEGMENT; HANTAAN VIRUS; RNA SEGMENT; MOLECULAR CHARACTERIZATION; CODING CAPACITY; S-GENOME; BUNYAVIRUSES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
W.W. Henderson et al., "NATURALLY-OCCURRING SIN-NOMBRE VIRUS GENETIC REASSORTANTS", Virology, 214(2), 1995, pp. 602-610

Abstract

Genetic reassortment has been shown to play an important role in the evolution of several segmented RNA viruses and in the epidemiology of associated diseases. Sin Nombre (SN) virus is the cause of hantavirus pulmonary syndrome throughout the western United States. Like other hantaviruses, it possesses a genome consisting of th ree negative-sense RNA segments, S, M, and L. Recent analysis has demonstrated the presence of at least three different hantaviruses in Nevada and eastern California, including SN, Prospect Hill-like, and El Moro Canyon-like viruses. In addition, two distinct lineages of SN virus can be found in Peromyscus maniculatus rodents (sometimes in close proximity) trapped atstudy sites in this region. Data obtained by phylogenetic analysis ofsequence differences detected among the S, M, and L genome segments of these SN viruses are consistent with reassortment having taken placebetween SN virus genetic variants. The results suggest that M (and toa lesser extent S or L) genome segment flow occurs within SN virus populations in P. maniculatus in this region. No reassortment was detected between SN virus and other hantavirus types present in the area. This finding suggests that as genetic distance increases, the frequency of formation of Viable reassortants decreases, or that hantaviruses which are primarily maintained in different rodent hosts rarely have theopportunity to genetically interact. (C) 1995 Academic Press, Inc.

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Documento generato il 04/12/20 alle ore 04:02:21