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Titolo:
THE METABOLISM OF ALICYCLIC AMINES TO REACTIVE IMINIUM ION INTERMEDIATES
Autore:
GORROD JW; AISLAITNER G;
Indirizzi:
UNIV LONDON KINGS COLL,CHELSEA DEPT PHARM,MANRESA RD LONDON SW3 6LX ENGLAND
Titolo Testata:
European journal of drug metabolism and pharmacokinetics
fascicolo: 3, volume: 19, anno: 1994,
pagine: 209 - 217
SICI:
0378-7966(1994)19:3<209:TMOAAT>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
PYRIDINIUM METABOLITE; ENZYMATIC OXIDATION; COVALENT BINDING; CYANIDE ION; NICOTINE; CYTOCHROME-P-450; (S)-NICOTINE; PHENCYCLIDINE; LIVER; HALOPERIDOL;
Keywords:
ALICYCLIC AMINES; IMINIUM IONS; ALPHA-CARBONYL COMPOUNDS; COVALENT BINDING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
J.W. Gorrod e G. Aislaitner, "THE METABOLISM OF ALICYCLIC AMINES TO REACTIVE IMINIUM ION INTERMEDIATES", European journal of drug metabolism and pharmacokinetics, 19(3), 1994, pp. 209-217

Abstract

The evidence implicating the formation of iminiumions as reactive intermediates in the metabolism of alicyclic amines has been reviewed. The mechanism of formation of iminium ions and their conversion to alpha-carbonyl compoounds or demethylated amines is discussed. The use of asimple cyanide trapping technique for iminium ions has been demonstrated to monitor a large number of alicyclic drugs for iminium ion formation. The possible role of iminium ions in the pharmacology and toxicology of alicyclic amines is considered.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 16:38:12