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Titolo:
IMPAIRED TUMOR-GROWTH IN COLONY-STIMULATING-FACTOR-1 (CSF-1)-DEFICIENT, MACROPHAGE-DEFICIENT OP OP MOUSE - EVIDENCE FOR A ROLE OF CSF-1-DEPENDENT MACROPHAGES IN FORMATION OF TUMOR STROMA/
Autore:
NOWICKI A; SZENAJCH J; OSTROWSKA G; WOJTOWICZ A; WOJTOWICZ K; KRUSZEWSKI AA; MARUSZYNSKI M; AUKERMAN SL; WIKTORJEDRZEJCZAK W;
Indirizzi:
CENT CLIN HOSP,MIL SCH MED,DEPT IMMUNOL PL-00909 WARSAW POLAND CENT CLIN HOSP,MIL SCH MED,DEPT IMMUNOL PL-00909 WARSAW POLAND WARSAW ACAD MED & HOSP,INST BIOSTRUCT WARSAW POLAND CHIRON CORP EMERYVILLE CA 94608
Titolo Testata:
International journal of cancer
fascicolo: 1, volume: 65, anno: 1996,
pagine: 112 - 119
SICI:
0020-7136(1996)65:1<112:ITIC(>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
LUNG-CARCINOMA CELLS; MICE; CSF-1; DIFFERENTIATION; POPULATIONS; EXPRESSION; MELANOMA; GENE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
A. Nowicki et al., "IMPAIRED TUMOR-GROWTH IN COLONY-STIMULATING-FACTOR-1 (CSF-1)-DEFICIENT, MACROPHAGE-DEFICIENT OP OP MOUSE - EVIDENCE FOR A ROLE OF CSF-1-DEPENDENT MACROPHAGES IN FORMATION OF TUMOR STROMA/", International journal of cancer, 65(1), 1996, pp. 112-119

Abstract

Macrophages have been suggested to play a major role in the immune response to cancer. They have also been suggested to stimulate the formation of tumor stroma and to promote tumor vascularization. The availability of the op/op mouse, which has no endogenous colony-stimulating factor 1 (CSF-1) and which possesses a profound macrophage deficiency, provides a new model to verify these notions. Subcutaneous growth of transplantable Lewis lung cancer (LLC) is markedly impaired in the op/op mice compared with normal littermates. Treatment of tumor-bearing op/op mice with human recombinant CSF-1 corrects this impairment. Histological analysis of tumors grown in op/op and normal mice revealed marked differences. Tumors grown in op/op mice display a decreased mitoticindex and pronounced necrosis, particularly hemorrhagic. Moreover, particularly in the op/op tumors, peculiar sinusoid-like abortive vessels (not filled with blood) have been observed. These tumors, in contrast to tumors grown in normal mice, are almost deprived of regular arteries and veins. In contrast to tumors grown in normal mice, they exhibit almost no Sirius red-stained collagenous fibers and Gomori silver-stained reticular fibers. Our data suggest that the CSF-1-dependent macrophage subpopulation missing in op/op mice plays a primary role in supporting tumor stroma formation and tumor vascularization in murine LLCtumors. (C) 1996 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 22:50:12