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Titolo:
A MULTICENTER STUDY TO EVALUATE THE EFFICACY AND SAFETY OF LISINOPRILIN PATIENTS WITH CHRONIC RENAL-INSUFFICIENCY
Autore:
CINOTTI GA; MORABITO S; ANDREUCCI V; BAZZATO G; BEDANI PL; BELLINI G; CAGLI V; BOSSINI A; CORATELLI P; IORIO L; MOLINELLI G; TIMIO M;
Indirizzi:
POLICLIN UMBERTO 1,INST MED CLIN 2,DIV NEPHROL I-00161 ROME ITALY UNIV ROMA LA SAPIENZA,DIV NEPHROL ROME ITALY
Titolo Testata:
JN. Journal of nephrology
fascicolo: 6, volume: 8, anno: 1995,
pagine: 320 - 324
SICI:
1121-8428(1995)8:6<320:AMSTET>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONVERTING ENZYME-INHIBITION; LYSINE ANALOG MK-521; RENOVASCULAR HYPERTENSION; DIABETIC NEPHROPATHY; ENALAPRIL MALEATE; ARTERY STENOSIS; CAPTOPRIL; RATS;
Keywords:
CHRONIC RENAL INSUFFICIENCY; HYPERTENSION; LISINOPRIL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
G.A. Cinotti et al., "A MULTICENTER STUDY TO EVALUATE THE EFFICACY AND SAFETY OF LISINOPRILIN PATIENTS WITH CHRONIC RENAL-INSUFFICIENCY", JN. Journal of nephrology, 8(6), 1995, pp. 320-324

Abstract

Seventy-nine patients with sitting DBP greater than or equal to 95 and less than or equal to 120 mmHg and Cl(cr)greater than or equal to 10and less than or equal to 60 ml/min/1.73 m(2), were recruited from general practice in ten different centers. A placebo washout period of two weeks was followed by 12 weeks monotherapy with lisinopril. The initial dose (5-10 mg) was doubled on a biweekly basis to a max of 40 mg if DBP was greater than or equal to 95 mmHg, then additional diuretic therapy was allowed. At week 12 DBP was less than or equal to 90 mmHg in 80% of patients. No patient was withdrawan because of severe clinical or laboratory adverse events, though serum potassium (S-k) significantly increased. As mean S-cr and C-cr did not change and acute renal deterioration never occurred. We conclude that lisinopril was well tolerated, significantly lowering BP in the majority of patients with chronic renal insufficiency. The possibility of severe hyperkalemia callsfor careful monitoring of S-k.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 06:47:15