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Titolo:
NEUROTROPIN INHIBITS HUMAN-IMMUNODEFICIENCY-VIRUS (HIV)-INDUCED SYNCYTIUM FORMATION
Autore:
TAKEOKA Y; YASHIKI S; IMAI H; MARUYAMA I; GERSHWIN ME; SUEHIRO S; SONODA S;
Indirizzi:
UNIV CALIF DAVIS,SCH MED,DIV RHEUMATOL ALLERGY & CLIN IMMUNOL,TB 192 DAVIS CA 95616 KAGOSHIMA UNIV,FAC MED,DEPT VIROL KAGOSHIMA 890 JAPAN NIPPON ZOKI PHARMACEUT CO LTD,INST BIOACT SCI,DIV BIOCHEM YASHIRO HYOGO 67314 JAPAN KAGOSHIMA UNIV,FAC MED,DEPT LAB MED KAGOSHIMA 890 JAPAN
Titolo Testata:
International journal of immunotherapy
fascicolo: 3, volume: 11, anno: 1995,
pagine: 95 - 102
SICI:
0255-9625(1995)11:3<95:NIH(S>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEFICIENCY SYNDROME AIDS; T-CELL; INFECTION; PATHOGENESIS; LYMPHOCYTES; REPLICATION; EXPRESSION; PROTEINS; ANTIGEN; BINDING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
Y. Takeoka et al., "NEUROTROPIN INHIBITS HUMAN-IMMUNODEFICIENCY-VIRUS (HIV)-INDUCED SYNCYTIUM FORMATION", International journal of immunotherapy, 11(3), 1995, pp. 95-102

Abstract

Development of effective therapeutic programmes that are useful during the early phase of HIV-1 (human immunodeficiency virus type-1) infection is a critical goal. Indeed, many patients remain asymptomatic foryears before the development of clinical manifestations. Neurotropin,a well-characterized immune modulator, is known to inhibit HIV production in vitro (1). To further understand the relationship between effects of Neurotropin and cytopathic effects of HIV-1, the authors investigated Neurotropin-responsive molecules expressed on the HIV-infected T-cell line (MT-2) and the effect of Neurotropin on HIV-induced syncytium formation. The protein extracts from HIV-infected MT-2 cells treated with or without Neurotropin were analysed by two-dimensional polyacrylamide gel electrophoresis (2-D PAGE). Four protein molecules, designated as HMP (HIV-induced MT-2 Protein) 1, 2, 3 and 4 which were not HIV components but cellular products were derived from infected MT-2 cells. The isoelectric point of HMP-1 changed from 5.8 to 5.6 upon Neurotropin treatment. The isoelectric point of HMP-2, HMP-3 and HMP-4 did not change after Neurotropin treatment. When MT-2 cells were pretreated with 10 to 100 mu g/ml of Neurotropin, HIV-induced syncytium formation was inhibited by 70% as compared to those of untreated MT-2 cells. These results suggest that HMP-1 inhibited syncytium formation by HIV-1 infected MT-2 cells may be a target of the bioactive effect of Neurotropin.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 01:07:44