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Titolo:
B-CELLS ARE GENERATED THROUGHOUT LIFE IN HUMANS
Autore:
NUNEZ C; NISHIMOTO N; GARTLAND GL; BILLIPS LG; BURROWS PD; KUBAGAWA H; COOPER MD;
Indirizzi:
UNIV ALABAMA,DEPT MED,DIV DEV & CLIN IMMUNOL,378 WALLACE TUMOR INST BIRMINGHAM AL 35294 UNIV ALABAMA,DEPT MED,DIV DEV & CLIN IMMUNOL BIRMINGHAM AL 35294 UNIV ALABAMA,DEPT MICROBIOL BIRMINGHAM AL 35294 UNIV ALABAMA,DEPT PATHOL BIRMINGHAM AL 35294 UNIV ALABAMA,DEPT PEDIAT BIRMINGHAM AL 35294 HOWARD HUGHES MED INST BIRMINGHAM AL 35294
Titolo Testata:
The Journal of immunology
fascicolo: 2, volume: 156, anno: 1996,
pagine: 866 - 872
SICI:
0022-1767(1996)156:2<866:BAGTLI>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
FLOW CYTOMETRIC ANALYSIS; ANTIBODY-FORMING-CELLS; HUMAN-BONE-MARROW; MONOCLONAL-ANTIBODIES; LEUKEMIA ANTIGEN; YOLK-SAC; PRECURSORS; DIFFERENTIATION; SUBPOPULATIONS; LYMPHOCYTES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
51
Recensione:
Indirizzi per estratti:
Citazione:
C. Nunez et al., "B-CELLS ARE GENERATED THROUGHOUT LIFE IN HUMANS", The Journal of immunology, 156(2), 1996, pp. 866-872

Abstract

This analysis of B cell development as a function of age reveals a relatively widespread distribution of progenitor B (pro-B), pre-B, and Bcells in fetal tissues, and thus supports the idea of a multifocal origin of B lineage cells during embryonic development, From mid-gestation onward, the bone marrow is the major site of B cell generation in humans, A relatively constant ratio of bone marrow precursors to B cells of immature phenotype (CD24(high)CD10(+)CD20(low)IgD(-)) is maintained from mid-gestation through the eighth decade of life, The persistence of recombinase gene activity in pro-B cells further attests the sustained production of B cells in bone marrow, Interestingly, a subpopulation of B cells with mature phenotype (CD24(low)CD10(-)CD20(high)IgD()) accumulates in the bone marrow during childhood, and this becomes the predominant B cell subpopulation in adult bone marrow, This maturepopulation of bone marrow B cells may represent a subpopulation of recirculating B cells that have undergone selection in the periphery.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 19:12:46