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Titolo:
3-BENZISOTHIAZOLYLPIPERAZINE DERIVATIVES AS POTENTIAL ATYPICAL ANTIPSYCHOTIC AGENTS
Autore:
HOWARD HR; LOWE JA; SEEGER TF; SEYMOUR PA; ZORN SH; MALONEY PR; EWING FE; NEWMAN ME; SCHMIDT AW; FURMAN JS; ROBINSON GL; JACKSON E; JOHNSON C; MORRONE J;
Indirizzi:
PFIZER INC,DIV CENT RES,EASTERN POINT RD GROTON CT 06340
Titolo Testata:
Journal of medicinal chemistry
fascicolo: 1, volume: 39, anno: 1996,
pagine: 143 - 148
SICI:
0022-2623(1996)39:1<143:3DAPAA>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
RISPERIDONE; RECEPTORS; PERSPECTIVES; HALOPERIDOL; HYDROLYSIS; SEROTONIN; DRUGS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
H.R. Howard et al., "3-BENZISOTHIAZOLYLPIPERAZINE DERIVATIVES AS POTENTIAL ATYPICAL ANTIPSYCHOTIC AGENTS", Journal of medicinal chemistry, 39(1), 1996, pp. 143-148

Abstract

A series of substituted phenethyl derivatives of 3-benzisothiazolylpiperazine incorporating potent D-2 and 5-HT2A antagonist activity was investigated as an approach to a novel atypical antipsychotic agent. The in vitro profile of 8e from this series is a combination of D-2 receptor affinity comparable to the typical antipsychotic agent haloperidol and a 5-HT2A/D-2 ratio comparable to the atypical agent clozapine. In vivo 8e possesses activity consistent with an efficacious antipsychotic agent with less tendency to induce extrapyramidal side effects in man.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 02:04:05