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Titolo:
THE EFFECT OF ACUTE VS CHRONIC TREATMENT WITH BETA-ADRENOCEPTOR BLOCKADE ON EXERCISE PERFORMANCE, HEMODYNAMIC AND METABOLIC PARAMETERS IN HEALTHY-MEN AND WOMEN
Autore:
GULLESTAD L; HALLEN J; MEDBO JI; GRONNEROD O; HOLME I; SEJERSTED OM;
Indirizzi:
UNIV OSLO,RIKSHOSP,DEPT MED B N-0027 OSLO NORWAY NATL INST OCCUPAT HLTH,DEPT PHYSIOL N-0033 OSLO NORWAY ULLEVAL HOSP,INST MED STAT,LIFE INSURANCE CO OSLO NORWAY
Titolo Testata:
British journal of clinical pharmacology
fascicolo: 1, volume: 41, anno: 1996,
pagine: 57 - 67
SICI:
0306-5251(1996)41:1<57:TEOAVC>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADRENERGIC-BLOCKADE; SEX-DIFFERENCES; HYPERTENSIVE MEN; SUBMAXIMAL EXERCISE; TREADMILL EXERCISE; ISOMETRIC-EXERCISE; CHRONIC INGESTION; DYNAMIC EXERCISE; HUMAN-HEART; PROPRANOLOL;
Keywords:
PROPANOLOL; HEART RATE; SUBJECTIVE PERCEPTION OF FATIGUE; MAXIMAL WORK; OXYGEN UPTAKE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
51
Recensione:
Indirizzi per estratti:
Citazione:
L. Gullestad et al., "THE EFFECT OF ACUTE VS CHRONIC TREATMENT WITH BETA-ADRENOCEPTOR BLOCKADE ON EXERCISE PERFORMANCE, HEMODYNAMIC AND METABOLIC PARAMETERS IN HEALTHY-MEN AND WOMEN", British journal of clinical pharmacology, 41(1), 1996, pp. 57-67

Abstract

1 Variable results have been reported on the effect of beta-adrenoceptor blockers on maximal oxygen uptake (VO2 max) and exercise endurance. This may in part be due to different subject populations, but it could also be due to an adaption of metabolic and haemodynamic responses to exercise during chronic treatment with beta-adrenoceptor blockers. The present study was therefore carried out to examine the effect of acute and chronic administration of the non-selective beta-adrenoceptorblocker propranolol on both peak VO2 and exercise performance in the same subjects. Since the effect of beta-adrenoceptor blockade has not been properly investigated in women, eight healthy women were comparedwith seven men. Progressive bicycle exercise to exhaustion was performed after propranolol 0.15 mg kg(-1) i.v. (acute) or 80 mg three timesdaily for 2 weeks (chronic) or placebo given according to a double-blind crossover design. 2 Mean (s.e. mean) peak VO2, was significantly reduced from 42.3 (1.6)ml min(-1)kg(-1) during placebo to 40.3 (1.2, P<0.05) ml min(-1)kg(-1) after acute and 39.1 (1.2, P<0.001)ml min(-1)kg(-1) after chronic propranolol treatment. No significant difference inpeak VO2, between the two propranolol treatment regimens was observed(mean difference 1.2, 95% CI -0.1 to 2.4ml min(-1) kg(-1)). There wasno treatment interaction with gender. 3 Cumulative work, 163 (9.3)kJ,was significantly reduced by acute, 148 (7.7, P < 0.001) kJ, and chronic, 147 (7.6, P < 0.001) kJ, administration of propranolol since the time to exhaustion was reduced by 5.3% and 5.3%, respectively. There was no significant difference between the two regimens of propranolol (mean difference 0.2, 95% CI -6.7 to 7.0 kJ) or between the sexes. Maximal knee extensor and handgrip strengths were not affected by propranolol. 4 Whereas sex did not influence ventilatory, haemodynamic or metabolic parameters, some differences were observed between acute and chronic propranolol treatment During submaximal exercise oxygen uptake was reduced by approximately 2% and RER values increased by 0.04-0.05 after chronic treatment in contrast to no effect of acute propranolol treatment. Heart rate and systolic blood pressure were reduced significantly more after chronic compared with acute propranolol treatment; peak heart rate being 186 (2.2), 147 (2.3) and 134 (2.3) beats min(-1), and peak systolic blood pressure being 189 (7), 171 (4) and 161 (4) mmHg after placebo, acute and chronic propranolol administration, respectively. Also the exercise induced rise in potassium and lactate levels were modified differentially; the rise in potassium concentration was less after chronic compared with acute propranolol treatment and lactate levels were reduced only after chronic administration of propranolol. In contrast, ventilation, which was unchanged after propranolol during submaximalexercise, was reduced to similar extent at exhaustion from 108 (6.4) to 97 (7.2) and 96 (5.9)1 min(-1) after acute and chronicpropranolol administration, respectively. Diastolic blood pressure and subjective perception of fatigue were similar across the treatment regimens. 5 The study has demonstrated that acute and chronic administration of propranolol result in different haemodynamic and metabolic response to exercise, although endurance and peak oxygen consumption were reduced to the same extent. The response to propranolol was not significantly different between men and women.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 15:09:42