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Titolo:
ENDOTHELIN RECEPTOR SUBTYPES AND THEIR ROLE IN TRANSMEMBRANE SIGNALING MECHANISMS
Autore:
SOKOLOVSKY M;
Indirizzi:
TEL AVIV UNIV,GEORGE S WISE FAC LIFE SCI,LAB NEUROBIOCHEM IL-69978 TEL AVIV ISRAEL
Titolo Testata:
Pharmacology & therapeutics
fascicolo: 3, volume: 68, anno: 1995,
pagine: 435 - 471
SICI:
0163-7258(1995)68:3<435:ERSATR>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE CELLS; RAT MESANGIAL CELLS; INCREASED PLASMA ENDOTHELIN-1; PROTEIN KINASE-C; DISTANCE GEOMETRY CALCULATIONS; ACUTE MYOCARDIAL-INFARCTION; NITRIC-OXIDE FORMATION; PHOSPHOLIPASE-C; PHOSPHOINOSITIDE HYDROLYSIS; ADENYLATE-CYCLASE;
Keywords:
ENDOTHELINS; SARAFOTOXINS; RECEPTOR SUBTYPES; CLONING; PHOSPHOLIPASES; CAMP; CGMP;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
208
Recensione:
Indirizzi per estratti:
Citazione:
M. Sokolovsky, "ENDOTHELIN RECEPTOR SUBTYPES AND THEIR ROLE IN TRANSMEMBRANE SIGNALING MECHANISMS", Pharmacology & therapeutics, 68(3), 1995, pp. 435-471

Abstract

The endothelins (ETs) are potent vasoactive peptides that appear to be involved in diverse biological actions, for example, contraction, neuromodulation, and neurotransmission, as well as in various pathophysiological conditions, such as renal and heart failure. The diversity ofactions of ETs may be explained in terms of (1) the existence of several receptor subtypes and (2) the activation of different signal transduction pathways. This review summarizes the state of the art in this intensively studied field, with particular focus on structural aspects, receptor heterogeneity, coupling of receptors to G-proteins, and signal transduction mechanisms mediated by the activation of ET-receptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 17:48:27