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Titolo:
PHOTODYNAMIC THERAPY OF SMALL ADENOCARCIN OMAS WITH METHYLENE-BLUE
Autore:
ORTH K; RUCK A; BECK G; STANESCU A; BEGER HG;
Indirizzi:
UNIV ULM,CHIRURG KLIN 1,STEINHOVELSTR 9 D-89075 ULM GERMANY INST LASERTECHNOL MED ULM GERMANY
Titolo Testata:
Chirurg
fascicolo: 12, volume: 66, anno: 1995,
pagine: 1254 - 1257
SICI:
0009-4722(1995)66:12<1254:PTOSAO>2.0.ZU;2-7
Fonte:
ISI
Lingua:
GER
Soggetto:
GASTRIC-CARCINOMA; PHOTOSENSITIZER; DESTRUCTION; CANCER; TUMORS;
Keywords:
PHOTODYNAMIC THERAPY; METHYLENE BLUE; ESOPHAGUS CARCINOMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
K. Orth et al., "PHOTODYNAMIC THERAPY OF SMALL ADENOCARCIN OMAS WITH METHYLENE-BLUE", Chirurg, 66(12), 1995, pp. 1254-1257

Abstract

Photodynamic therapy (PDT) is a new method in the treatment of small/early malignancies. It is based on the interaction of a photosensitiser, light and cellular oxygen. A new therapeutic concept with locally applied 1 % of methylene blue into the tumour and subsequent radiation (argon laser pumped dye laser, 665 nm, 100 mW/cm(2), 100 J/cm(2)) was first tested in xenotransplanted carcinomas and then clinically applied. The animal experiments showed a tumour volume reduction of 1:12, ascompared to a control group, two weeks after the first PDT-application. After the second PDT-treatment 6 out of 10 tumours were destroyed. Four carcinomas showed inhibited growth after the treatment. The method was clinically applied in 3 patients with local tumour recurrence inthe area of the anastomosis after oesophagus resection. 72 hours after PDT-treatment 4-5 mm tumour necrosis could be proven experimentally. PDT was repeated at the same site within 2 weeks. There were no experimental or clinical complications during or after PDT. The treated tumour areas showed no local tumour growth within 6 months after PDT-treatment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 02:23:05