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Titolo:
ANGIOTENSIN-CONVERTING ENZYME AS A GENETIC RISK FACTOR FOR CORONARY-ARTERY SPASM - IMPLICATION IN THE PATHOGENESIS OF MYOCARDIAL-INFARCTION
Autore:
OIKE Y; HATA A; OGATA Y; NUMATA Y; SHIDO K; KONDO K;
Indirizzi:
HOKKAIDO UNIV,SCH MED,DEPT PUBL HLTH,N15,W7 SAPPORO HOKKAIDO 060 JAPAN HOKKAIDO UNIV,SCH MED,DEPT PUBL HLTH SAPPORO HOKKAIDO 060 JAPAN JAPANESE RED CROSS KUMAMOTO HOSP,DEPT CARDIOL KUMAMOTO 862 JAPAN
Titolo Testata:
The Journal of clinical investigation
fascicolo: 6, volume: 96, anno: 1995,
pagine: 2975 - 2979
SICI:
0021-9738(1995)96:6<2975:AEAAGR>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIUM-DEPENDENT VASODILATION; VARIANT ANGINA; DELETION POLYMORPHISM; RELAXING FACTOR; SYSTEM; VASOSPASM; SMOKING; SERUM;
Keywords:
POLYMORPHISM; CORONARY ANGIOGRAPHY; RENIN ANGIOTENSIN SYSTEM; ODDS RATIO; RISK FACTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
Y. Oike et al., "ANGIOTENSIN-CONVERTING ENZYME AS A GENETIC RISK FACTOR FOR CORONARY-ARTERY SPASM - IMPLICATION IN THE PATHOGENESIS OF MYOCARDIAL-INFARCTION", The Journal of clinical investigation, 96(6), 1995, pp. 2975-2979

Abstract

It has been reported that individuals with the D allele of an insertion/deletion (IID) polymorphism of the angiotensin converting enzyme (ACE) gene are at greater risk for myocardial infarction (MI), especially among subjects normally considered to be at low risk. However, little is known about the mechanism by which the ACE polymorphism affects the risk of MI, Coronary artery spasm (GAS) is considered to be one possible mechanism for developing MI, We therefore examined the ACE polymorphism relation to CAS to determine if this was the mechanism by which the DD genotype influences MI, We studied 150 angiographically assessed Japanese males, all more than 60 yr old, CASs were detected using intracoronary injection of ergonovine maleate. Subjects were divided into three groups: those with CAS (group 1), those without GAS, but with fixed organic stenosis (group 2); and those without CAS and no organic stenosis (group 3), DD subjects were significantly represented in group 1 when compared with groups 2 (P = 0.002) and 3 (P = 0.026). These results suggest that the DD genotype relates to the greater risk forMI in the patients with GAS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/21 alle ore 17:55:44