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Titolo:
INCREASED EXPRESSION OF SYNAPSIN-I MESSENGER-RNA IN DEFINED AREAS OF THE RAT CENTRAL-NERVOUS-SYSTEM FOLLOWING CHRONIC MORPHINE TREATMENT
Autore:
MATUSLEIBOVITCH N; EZRAMACABEE V; SAYA D; ATTALI B; AVIDORREISS T; BARG J; VOGEL Z;
Indirizzi:
WEIZMANN INST SCI,DEPT NEUROBIOL IL-76100 REHOVOT ISRAEL WEIZMANN INST SCI,DEPT NEUROBIOL IL-76100 REHOVOT ISRAEL TEL AVIV UNIV,SACKLER SCH MED,WOLFSON MED CTR,CARDIOVASC & HYPERTENS RES LAB IL-58100 HOLON ISRAEL
Titolo Testata:
Molecular brain research
fascicolo: 2, volume: 34, anno: 1995,
pagine: 221 - 230
SICI:
0169-328X(1995)34:2<221:IEOSMI>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
DORSAL-ROOT GANGLION; SYNAPTIC VESICLE PHOSPHOPROTEINS; OPIATE EXPOSURE LEADS; SPINAL-CORD; LOCUS COERULEUS; ADENYLATE-CYCLASE; SENSORY NEURONS; SUBSTANCE-P; OPIOID RECEPTORS; BRAIN;
Keywords:
MORPHINE; OPIATE TOLERANCE; SYNAPSIN I MESSENGER-RNA; LOCUS COERULEUS; AMYGDALA; SPINAL CORD; IN SITU HYBRIDIZATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
47
Recensione:
Indirizzi per estratti:
Citazione:
N. Matusleibovitch et al., "INCREASED EXPRESSION OF SYNAPSIN-I MESSENGER-RNA IN DEFINED AREAS OF THE RAT CENTRAL-NERVOUS-SYSTEM FOLLOWING CHRONIC MORPHINE TREATMENT", Molecular brain research, 34(2), 1995, pp. 221-230

Abstract

Chronic opiate administration leads to a selective regulation of several cellular proteins and mRNAs. This phenomenon has been viewed as a compensatory mechanism to the opiate signaling leading to the development of opiate addiction. In this study, in situ hybridization histochemistry experiments were employed to investigate the effect of chronic morphine treatment on synapsin I gene expression. We show here for thefirst time that prolonged morphine exposure causes a selective increase in the mRNA levels of synapsin I in several brain regions which areconsidered to be important for opiate action. Quantitative analysis of the signals, obtained by hybridization of digoxigenin-labeled antisense RNA probe, revealed a 5.8- and 7-fold increase of synapsin I mRNA levels in the locus coeruleus and the amygdala of morphine-treated rats, respectively, as compared with control untreated rats. Increased expression of synapsin I mRNA was also observed in the spinal cord of morphine-treated rats (by 3.8-fold). Since opiates were shown to attenuate neurotransmitter release and reduce synapsin I phosphorylation, it is suggested that the increase in synapsin I levels would lead to the requirement of higher amounts of opiate agonists to obtain the opiate physiological effects. These results suggest that the increases in mRNA levels of synapsin I in these specific areas can be part of the molecular mechanism(s) underlying opiate tolerance and withdrawal.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 16:03:39