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Titolo:
INTERACTION OF MOLECULES WITH DNA
Autore:
KUNJAPPU JT; VENKATACHALAM SR; NAIR CKK;
Indirizzi:
BHABHA ATOM RES CTR,DIV CHEM BOMBAY 400085 MAHARASHTRA INDIA BHABHA ATOM RES CTR,DIV BIOORGAN BOMBAY 400085 MAHARASHTRA INDIA BHABHA ATOM RES CTR,RADIAT BIOL & BIOCHEM DIV BOMBAY 400085 MAHARASHTRA INDIA
Titolo Testata:
Journal of Scientific & Industrial Research
fascicolo: 12, volume: 54, anno: 1995,
pagine: 717 - 736
SICI:
0022-4456(1995)54:12<717:IOMWD>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEAR-MAGNETIC-RESONANCE; ANTI-TUMOR AGENTS; CALF-THYMUS DNA; SEQUENCE-SELECTIVE BINDING; GENE-TOX PROGRAM; TOPOISOMERASE-II; GROOVE-BINDING; MINOR-GROOVE; 4',6-DIAMIDINO-2-PHENYLINDOLE DAPI; DEOXYRIBONUCLEIC-ACID;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
197
Recensione:
Indirizzi per estratti:
Citazione:
J.T. Kunjappu et al., "INTERACTION OF MOLECULES WITH DNA", Journal of Scientific & Industrial Research, 54(12), 1995, pp. 717-736

Abstract

The mutagenic, clastogenic, antitumor and antiviral activity of several chemicals have been ascribed to their abilities to interact with DNA. This review pertains to two main aspects of DNA ligand interactions, viz. DNA binding assay protocols and synthetic strategies for ligands interacting with DNA. Many physical and biological methods are available to-date to assess the DNA-binding potential of chemicals, both ofsynthetic and natural origin. Chemicals interact with DNA by different modes, such as intercalation, groove-binding and electrostatic interaction, depending on their molecular structure. Among the DNA binding assay protocols, the physicochemical methods and the biological methods are discussed. Various synthetic strategies, which have been adoptedto develop newer drugs and ligands having novel structural features to impart higher DNA binding efficiency as well as base pair specificity and selectivity, are highlighted.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 05:05:16