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Titolo:
PROLACTIN BINDING-SITES IN RAT-BRAIN AND LIVER - EFFECTS OF LONG-TERMOVARIECTOMY AND OVARIAN-STEROIDS
Autore:
MUSTAFA A; NYBERG F; BOGDANOVIC N; ISLAM A; SULIMAN I; LINDGREN U; ROOS P; ADEM A;
Indirizzi:
UPPSALA UNIV,DIV BIOL RES DRUG DEPENDENCE,DEPT PHARMACEUT BIOSCI UPPSALA SWEDEN UPPSALA UNIV,DIV BIOL RES DRUG DEPENDENCE,DEPT PHARMACEUT BIOSCI UPPSALA SWEDEN UNIV UPPSALA,DEPT BIOCHEM UPPSALA SWEDEN KAROLINSKA INST,HUDDINGE HOSP,DEPT GERIATR MED S-14186 HUDDINGE SWEDEN KAROLINSKA INST,HUDDINGE HOSP,DEPT ORTHOPAED SURG S-14186 HUDDINGE SWEDEN
Titolo Testata:
Neuroscience letters
fascicolo: 3, volume: 200, anno: 1995,
pagine: 179 - 182
SICI:
0304-3940(1995)200:3<179:PBIRAL>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAMMARY-GLAND; FEMALE RAT; PITUITARY; RECEPTORS; ESTRADIOL; STIMULATION; RELEASE;
Keywords:
LACTOGENIC BINDING SITES; LONG-TERM OVARIECTOMY; PROLACTIN; RAT BRAIN; RECEPTOR AUTORADIOGRAPHY; OVARIAN STEROIDS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
A. Mustafa et al., "PROLACTIN BINDING-SITES IN RAT-BRAIN AND LIVER - EFFECTS OF LONG-TERMOVARIECTOMY AND OVARIAN-STEROIDS", Neuroscience letters, 200(3), 1995, pp. 179-182

Abstract

The effects of long-term ovariectomy on the levels of brain and Ever lactogenic binding sites as well as plasma and liver prolactin (PRL) have been investigated in sham-operated and ovariectomized rats receiving either 17 beta estradiol (OVX-E), progesterone (OVX-P), or vehicle (OVX-V). The levels of lactogenic binding sites in the parietal and piriform cortices, amygdala, thalamus, hypothalamus, as well as in the liver were significantly decreased after long-term ovariectomy. Moreover, the levels of plasma and liver PRL were also significantly decreased. Exogenous estradiol and progesterone replacement restored the levels of lactogenic binding sites in the parietal cortex and hypothalamus as well as in the liver. However, plasma and liver PRL levels were significantly increased by estradiol but only restored by progesterone. These results suggest that ovarian steroids influence the levels of lactogenic binding sites and prolactin.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/08/20 alle ore 08:45:37