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Titolo:
REGIONAL CEREBRAL BLOOD-FLOW IN FIRST BREAK AND CHRONIC-SCHIZOPHRENICPATIENTS AND NORMAL CONTROLS
Autore:
STEINBERG JL; DEVOUS MD; PAULMAN RG; GREGORY RR;
Indirizzi:
UNIV TEXAS,HARRIS CTY PSYCHIAT CTR,2800 S MACGREGOR WAY,POB 20249 HOUSTON TX 77225 DEPT VET AFFAIRS MED CTR,PSYCHIAT SERV 116A DALLAS TX 75216 UNIV TEXAS,SW MED SCH,DEPT PSYCHIAT DALLAS TX 75235 UNIV TEXAS,SW MED SCH,DEPT RADIOL DALLAS TX 75235 UNIV TEXAS,SW MED SCH,CTR NUCL MED DALLAS TX 75235
Titolo Testata:
Schizophrenia research
fascicolo: 3, volume: 17, anno: 1995,
pagine: 229 - 240
SICI:
0920-9964(1995)17:3<229:RCBIFB>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
EMISSION COMPUTED-TOMOGRAPHY; DORSOLATERAL PREFRONTAL CORTEX; BRAIN GLUCOSE-METABOLISM; INERT-GAS CONCENTRATIONS; MEDICATED SCHIZOPHRENICS; PHYSIOLOGIC DYSFUNCTION; PSYCHIATRIC-DISORDERS; HYPOFRONTALITY; PERFUSION; ATTENTION;
Keywords:
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY; REGIONAL CEREBRAL BLOOD HOW; PREFRONTAL CORTEX; TEMPORAL CORTEX; DURATION OF ILLNESS; (SCHIZOPHRENIA);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
61
Recensione:
Indirizzi per estratti:
Citazione:
J.L. Steinberg et al., "REGIONAL CEREBRAL BLOOD-FLOW IN FIRST BREAK AND CHRONIC-SCHIZOPHRENICPATIENTS AND NORMAL CONTROLS", Schizophrenia research, 17(3), 1995, pp. 229-240

Abstract

Dynamic Xe-133 Single Photon Emission Computed Tomography (SPECT) wasused to measure the resting regional cerebral blood flow (rCBF) in 16neuroleptic free schizophrenic and schizophreniform male patients and13 age-matched male normal controls. A subgroup consisting of 'first break' patients who had never been exposed to neuroleptic treatment were age-matched to a subgroup of young chronic patients most of whom had been previously exposed to neuroleptics. The age-adjusted rCBF values were compared among first breaks, young chronics, normal controls, and a subgroup of older, more chronic patients. In first break patients, we found significantly lower absolute global cerebral blood flow andsignificantly lower superior frontal, middle frontal, and middle temporal absolute rCBF compared to normals. We also found significantly lower relative superior frontal rCBF in first breaks vs. normals, and higher relative superior frontal and relative middle frontal rCBF in older chronics vs. the other groups. For relative posterior temporal rCBFthere was greater asymmetry (right side > left) in first breaks and young chronics compared to normals and older chronics.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 16:03:27