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Titolo:
CHOLECYSTOKININ INCREASES SMALL-INTESTINAL MOTILITY AND REDUCES ENTERIC BACTERIAL OVERGROWTH AND TRANSLOCATION IN RATS WITH SURGICALLY INDUCED ACUTE LIVER-FAILURE
Autore:
WANG XD; SOLTESZ V; AXELSON J; ANDERSSON R;
Indirizzi:
UNIV LUND HOSP,DEPT SURG S-22185 LUND SWEDEN UNIV LUND HOSP,DEPT SURG S-22185 LUND SWEDEN UNIV LUND HOSP,DEPT CLIN MICROBIOL S-22185 LUND SWEDEN
Titolo Testata:
Digestion
fascicolo: 1, volume: 57, anno: 1996,
pagine: 67 - 72
SICI:
0012-2823(1996)57:1<67:CISMAR>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
PEPTIDES; HEPATECTOMY; COMPLEX; FLORA; DOGS;
Keywords:
CHOLECYSTOKININ; BACTERIAL OVERGROWTH; TRANSLOCATION; MOTILITY; HEPATECTOMY; ACUTE LIVER FAILURE; INTESTINE; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
X.D. Wang et al., "CHOLECYSTOKININ INCREASES SMALL-INTESTINAL MOTILITY AND REDUCES ENTERIC BACTERIAL OVERGROWTH AND TRANSLOCATION IN RATS WITH SURGICALLY INDUCED ACUTE LIVER-FAILURE", Digestion, 57(1), 1996, pp. 67-72

Abstract

Enteric bacterial translocation into extraintestinal sites has been proposed as a potential route for bacterial infection in acute liver failure. Bacterial overgrowth in the intestine plays an important role in the etiology of bacterial translocation from the gut. The aim of thepresent study was to evaluate the influence of exogenous cholecystokinin (CCK) on intestinal transit time, enteric bacterial overgrowth andtranslocation in experimental acute liver failure induced by 90% hepatectomy. A delayed intestinal transit time was noted in animals subjected by subtotal hepatectomy after 1 h, followed by enteric bacterial overgrowth and translocation into the systemic circulation, mesenteric lymph nodes, and systemic organs at 2 and 4 h. Intravenous infusion ofCCK stimulated intestinal transit time in animals with sham operationand subtotal hepatectomy, though a restoration to sham levels could not be obtained in the later. Moreover, enteric bacterial overgrowth and translocation were prevented in hepatectomized animals. The present data imply that impaired intestinal motility, followed by enteric bacterial overgrowth and translocation in experimental acute liver failure, could be prevented by CCK infusion.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 14:02:15