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Titolo:
UPTAKE BY CELLS AND PHOTOSENSITIZING EFFECTIVENESS OF NOVEL PHEOPHORBIDE DERIVATIVES IN-VITRO
Autore:
DAGAN A; GATT S; CERBUKARABAT S; MAZIERE JC; MAZIERE C; SANTUS R; ENGELHARDT EL; YEH KA; STOBBE CC; FENNING MC; CHAPMAN JD;
Indirizzi:
MUSEUM NATL HIST NAT,PHYSICOCHIM ADAPTAT BIOL LAB,INSERM,U312,43 RUE CUVIER F-75231 PARIS 05 FRANCE MUSEUM NATL HIST NAT,PHYSICOCHIM ADAPTAT BIOL LAB,INSERM,U312 F-75231PARIS 05 FRANCE HEBREW UNIV JERUSALEM,HADASSAH MED SCH,DEPT BIOCHEM IL-91120 JERUSALEM ISRAEL UNIV PARIS 06,FAC MED ST ANTOINE,BIOCHEM LAB F-75571 PARIS 12 FRANCE FOX CHASE CANC CTR,DEPT RADIAT ONCOL PHILADELPHIA PA 19111
Titolo Testata:
International journal of cancer
fascicolo: 6, volume: 63, anno: 1995,
pagine: 831 - 839
SICI:
0020-7136(1995)63:6<831:UBCAPE>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY-LIPOPROTEIN; PHOTODYNAMIC THERAPY; PHOTOFRIN-II; INVITRO;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
A. Dagan et al., "UPTAKE BY CELLS AND PHOTOSENSITIZING EFFECTIVENESS OF NOVEL PHEOPHORBIDE DERIVATIVES IN-VITRO", International journal of cancer, 63(6), 1995, pp. 831-839

Abstract

Pheophorbide a prepared from the algae Spirulina was derivatized at the C(7)-carboxylic group by linking amino alkyls of various lengths and terminal functional groups. The compounds were purified by thin-layer chromatography (TLC) and by high-pressure liquid chromatography (HPLC). Solubilization of compounds by serum lipoproteins, the kinetics ofcompound uptake into mammalian cells, and photosensitizing effectiveness when activated by 673 nm laser light have been studied. Optimal photosensitizer uptake into cells and the greatest photosensitizing activity were observed with compounds having side-chain lengths of 4-6 carbon atoms which terminated in -OH and -CH3 groups. The most effective compounds were 3 orders of magnitude more potent than Photofrin in thedegree of photoinactivation of cultured EMT-6 tumor cells. HDL and LDL significantly promoted the efflux of these photosensitizing drugs from cells, suggesting that their long-term retention in normal tissues in vivo would be minimal and produce little phototoxicity. (C) 1995 Wilty-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 01:47:19