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Titolo:
PLASMA-LEVELS AND MOLECULAR-FORMS OF PROATRIAL NATRIURETIC PEPTIDES IN HEALTHY-SUBJECTS AND IN PATIENTS WITH CONGESTIVE-HEART-FAILURE
Autore:
AZIZI C; MAISTRE G; KALOTKA H; ISNARD R; BARTHELEMY C; MASSON F; PHAM P; POUSSET F; EURIN J; LECHAT P; KOMAJDA M; CARAYON A;
Indirizzi:
CHU PITIE SALPETRIERE,SERV BIOCHIM,91 BD HOP F-75674 PARIS 13 FRANCE CHU PITIE SALPETRIERE,SERV CARDIOL F-75674 PARIS 13 FRANCE CHU PITIE SALPETRIERE,SERV PHARMACOL F-75674 PARIS 13 FRANCE CEA SACLAY,SERV MOLEC MARQUEES F-91191 GIF SUR YVETTE FRANCE
Titolo Testata:
Journal of Endocrinology
fascicolo: 1, volume: 148, anno: 1996,
pagine: 51 - 57
SICI:
0022-0795(1996)148:1<51:PAMOPN>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
LEFT-VENTRICULAR DYSFUNCTION; N-TERMINAL FRAGMENT; ESSENTIAL-HYPERTENSION; NH2-TERMINAL FRAGMENT; ATRIAL DISTENSION; FACTOR PRECURSOR; PROHORMONE; RELEASE; IDENTIFICATION; POLYPEPTIDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
C. Azizi et al., "PLASMA-LEVELS AND MOLECULAR-FORMS OF PROATRIAL NATRIURETIC PEPTIDES IN HEALTHY-SUBJECTS AND IN PATIENTS WITH CONGESTIVE-HEART-FAILURE", Journal of Endocrinology, 148(1), 1996, pp. 51-57

Abstract

A specific and sensitive radioimmunoassay (RIA) for the N-terminal fragment of proatrial natriuretic peptide (NproANP) was developed. Antiserum raised in rabbits against a mixture enriched with prohormone was 100% cross-reactive with human proANP(1-30). Plasma concentrations of proANP(1-30) and ANP immunoreactivities (ir-) were simultaneously measured in healthy subjects and patients with congestive heart failure (CHF; 26 dilated cardiomyopathy and 5 ischemic heart disease). High plasma levels of both ir-proANP(1-30) and ir-ANP were detected in CHF patients. Circulating ir-ANP levels were elevated in New York Heart Association functional Classes II and III patients but not in Class I patients. However, plasma levels of ir-proANP(1-30) were higher in asymptomatic patients than in healthy subjects, and markedly increased in patients of Classes II and III. Analysis of ir-proANP(1-30) by ge filtration chromatography or reverse-phase high pressure liquid chromatography revealed a 10 kDa peptide circulating as a distinct entity. These findings indicate that: (i) the most probable form of NproANP in human plasma is a 10 kDa peptide and (ii) in CHF patients the rise in plasma ir-proANP(1-30) levels is more pronounced than the variation in plasma ir-ANP. Thus, NproANP plasma levels may prove to be a more sensitive marker of left ventricular dysfunction than ANP.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 22:24:43