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Titolo:
A STUDY OF OLIGOCLONAL BAND NEGATIVE MULTIPLE-SCLEROSIS
Autore:
ZEMAN AZJ; KIDD D; MCLEAN BN; KELLY MA; FRANCIS DA; MILLER DH; KENDALL BE; RUDGE P; THOMPSON EJ; MCDONALD WI;
Indirizzi:
ADDENBROOKES HOSP,DEPT NEUROL,HILLS RD CAMBRIDGE CB2 2QQ ENGLAND UNIV LONDON,INST NEUROL LONDON WC1N 3BG ENGLAND UNIV BIRMINGHAM,QUEEN ELIZABETH HOSP,DEPT NEUROL BIRMINGHAM B15 2TH WMIDLANDS ENGLAND
Titolo Testata:
Journal of Neurology, Neurosurgery and Psychiatry
fascicolo: 1, volume: 60, anno: 1996,
pagine: 27 - 30
SICI:
0022-3050(1996)60:1<27:ASOOBN>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNOGLOBULIN-G; GUIDELINES; DIAGNOSIS;
Keywords:
MULTIPLE SCLEROSIS; OLIGOCLONAL BANDS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
A.Z.J. Zeman et al., "A STUDY OF OLIGOCLONAL BAND NEGATIVE MULTIPLE-SCLEROSIS", Journal of Neurology, Neurosurgery and Psychiatry, 60(1), 1996, pp. 27-30

Abstract

Objectives-to determine whether oligoclonal band (OCB) negative multiple sclerosis is a reliable diagnosis and, if so, whether it has a distinctive prognosis. Methods-retrospective and matched prospective comparison of the clinical and laboratory features of patients with clinical definite multiple sclerosis with and without intrathecal synthesis of oligoclonal IgG. Results-thirty four patients were identified with apparent OCB negative clinically definite multiple sclerosis. The results of oligoclonal banding proved to have been equivocal in 14 of 34; the clinical diagnosis of multiple sclerosis was questionable in 8 of 34. The remaining 12 patients with ''true'' OCB negative multiple sclerosis were significantly less disabled than matched OCB positive controls. Re-examination of CSF-serum pairs from six OCB negative patients showed that three remained OCB negative while three showed evidence ofintrathecal synthesis of OCBs. Conclusions-OCB negative clinically definite multiple sclerosis is rare and should be diagnosed with caution; in unequivocal cases it seems to have a relatively benign prognosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 10:11:36