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Titolo:
FILLING CHARACTERISTICS OF LEFT-VENTRICLE IN NEWBORN LAMBS
Autore:
VELVIS H; KLOPFENSTEIN HS;
Indirizzi:
WAKE FOREST UNIV,BOWMAN GRAY SCH MED,DEPT PEDIAT,CARDIOL SECT,MED CTRBLVD WINSTON SALEM NC 27157 WAKE FOREST UNIV,BOWMAN GRAY SCH MED,DEPT INTERNAL MED WINSTON SALEM NC 27157
Titolo Testata:
American journal of physiology. Heart and circulatory physiology
fascicolo: 6, volume: 38, anno: 1995,
pagine: 2039 - 2043
SICI:
0363-6135(1995)38:6<2039:FCOLIN>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEVELOPMENTAL-CHANGES; VOLUME; MECHANISM; RESPONSES; PRESSURE; EXERCISE; OXYGEN; FLOW;
Keywords:
LEFT ATRIAL FUNCTION; DIASTOLE; CONGESTIVE HEART FAILURE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
H. Velvis e H.S. Klopfenstein, "FILLING CHARACTERISTICS OF LEFT-VENTRICLE IN NEWBORN LAMBS", American journal of physiology. Heart and circulatory physiology, 38(6), 1995, pp. 2039-2043

Abstract

An integral component of increased cardiac performance during the immediate newborn period is an increased rate of left ventricular (LV) filling. To determine the factors that facilitate increased LV filling in newborns, we compared filling characteristics in chronically instrumented awake newborn (7 +/- 2 days old) and older lambs (55 +/- 5 days old). The studies were performed 4 +/- 2 days after surgery, during which pressure transducers, dimension crystals, a flow transducer, and vascular occluders were placed. Newborn lambs had an increased cardiac index (247 +/- 40 vs. 127 +/- 48 ml . kg(-1). min(-1); P < 0.01) due to an increased heart rate (223 +/- 24 vs. 120 +/- 9 beats/min; P < 0.01) despite a similar stroke volume index (1.1 +/- 0.1 vs. 1.1 +/- 0.5 ml/kg; not significant). In newborn lambs, indexed mean LV filling rates were more than twofold higher (10.5 +/- 2.5 vs. 4.6 +/- 1.7 ml . kg(-1). s(-1); P < 0.01), and a much greater percentage of filling occurred in the first 35 ms after mitral valve opening (52 +/- 7 vs. 23 +/-8%; P < 0.01). In newborn lambs, early diastolic filling was facilitated by more rapid LV relaxation (tau: 17.2 +/- 2.2 vs. 23.3 +/- 1.2 ms; P < 0.01) and a higher left atrial (LA) pressure at the time of mitral valve opening (11.6 +/- 2.4 vs. 7.2 +/- 3.2 mmHg; P < 0.05). LV filling in newborn lambs also occurred at the expense of a higher mean LApressure (8.4 +/- 2.4 vs. 5.1 +/- 2.6 mmHg; P < 0.05). These findingsimprove our understanding of LV diastolic function in newborns.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 06:52:40