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Titolo:
NIGROFRONTAL DOPAMINERGIC FUNCTION AS ASSESSED BY F-18 DOPA PET
Autore:
OTSUKA M; ICHIYA Y; KUWABARA Y; SASAKI M; YOSHIDA T; FUKUMURA T; MASUDA K;
Indirizzi:
KYUSHU UNIV,FAC MED,MED INST BIOREGULAT,DEPT RADIOL,4546 TSUSRUMIHARABEPPU 874 OITA JAPAN
Titolo Testata:
Nuclear medicine communications
fascicolo: 12, volume: 16, anno: 1995,
pagine: 1021 - 1025
SICI:
0143-3636(1995)16:12<1021:NDFAAB>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; F-18 DOPA UPTAKE; GLUCOSE-METABOLISM; PARKINSONS-DISEASE; DEGENERATION; KINETICS; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
M. Otsuka et al., "NIGROFRONTAL DOPAMINERGIC FUNCTION AS ASSESSED BY F-18 DOPA PET", Nuclear medicine communications, 16(12), 1995, pp. 1021-1025

Abstract

The existence of the nigrofrontal dopaminergic pathway has been demonstrated in neuroanatomical studies. We evaluated the presynaptic nigrofrontal dopaminergic function using F-18-dopa (FD) positron emission tomography (PET). The multiple time PET data in the frontal cortex from20 to 70 min post-injection for FD were evaluated by Patlak analysis using the cerebellar time-activity curve as an input function. The frontal FD uptake rate constants could not be determined in 5 of 12 normal volunteers because of large deviations in the plots. There were no significant differences between the subjects among whom the frontal FD uptake rate constants could or could not be determined regarding the amount of FD injected, the frontal F-18 counts, or whether or not they were pretreated with carbidopa. The uptake constants were determined in 9 of 12 patients with parkinsonian syndrome. While the mean (+/-S.D.) uptake constants in patients with Parkinson's disease (2.89 +/- 0.06x 10(-3); n = 4) and in patients with progressive supranuclear palsy (2.81 +/- 0.10 x 10(-3); n = 3) were not significantly different from those in the normal volunteers (2.93 +/- 0.14 x 10(-3)), those in two patients with corticobasal degeneration (2.42 and 2.46, respectively) decreased in comparison to the control values. Differences in the nigrofrontal presynaptic dopaminergic function as assessed by ED-PET may explain the different pathogenesis and also help to differentiate between corticobasal degeneration and other parkinsonian syndromes, such asParkinson's disease and progressive supranuclear palsy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 15:07:20