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Titolo:
PERMUTATION TESTS FOR MULTIPLE LOCI AFFECTING A QUANTITATIVE CHARACTER
Autore:
DOERGE RW; CHURCHILL GA;
Indirizzi:
PURDUE UNIV,DEPT AGRON,1399 MATH SCI BLDG W LAFAYETTE IN 47907 CORNELL UNIV,BIOMETR UNIT ITHACA NY 14853
Titolo Testata:
Genetics
fascicolo: 1, volume: 142, anno: 1996,
pagine: 285 - 294
SICI:
0016-6731(1996)142:1<285:PTFMLA>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAXIMUM-LIKELIHOOD METHODS; TRAIT LOCI; MENDELIAN FACTORS; GENETIC-MARKERS; LINE CROSSES; LINKAGE MAPS; RESOLUTION; AID;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
R.W. Doerge e G.A. Churchill, "PERMUTATION TESTS FOR MULTIPLE LOCI AFFECTING A QUANTITATIVE CHARACTER", Genetics, 142(1), 1996, pp. 285-294

Abstract

The problem of detecting minor quantitative trait loci (QTL) responsible for genetic variation not explained by major QTL is of importance in the complete dissection of quantitative characters. Two extensions of the permutation-based method for estimating empirical threshold values are presented. These methods, the conditional empirical threshold (GET) and the residual empirical threshold (RET), yield critical values that can be used to construct tests for the presence of minor QTL effects while accounting for effects of known major QTL. The CET provides a completely nonparametric test through conditioning on markers linked to major QTL. It allows for general nonadditive interactions among QTL, but its practical application is restricted to regions of the genome that are unlinked to the major QTL. The RET assumes a structural model for the effect of major QTL, and a threshold is constructed usingresiduals from this structural model. The search space for minor QTL is unrestricted, and RET-based tests may be more powerful than the GET-based test when the structural model is approximately true.

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Documento generato il 14/07/20 alle ore 18:42:08