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Titolo:
GALACTOSEMIC NEUROPATHY IN TRANSGENIC MICE FOR HUMAN ALDOSE REDUCTASE
Autore:
YAGIHASHI S; YAMAGISHI SI; WADA R; SUGIMOTO K; BABA M; WONG HG; FUJIMOTO J; NISHIMURA C; KOKAI Y;
Indirizzi:
HIROSAKI UNIV,SCH MED,DEPT PATHOL,ZAIFU CHO 5 HIROSAKI AOMORI 036 JAPAN HIROSAKI UNIV,SCH MED,DEPT NEUROL HIROSAKI AOMORI 036 JAPAN NATL CHILDRENS MED RES CTR,DEPT PATHOL,SETAGAYA KU TOKYO 154 JAPAN NATL CHILDRENS MED RES CTR,DEPT PHARMACOL,SETAGAYA KU TOKYO 154 JAPAN
Titolo Testata:
Diabetes
fascicolo: 1, volume: 45, anno: 1996,
pagine: 56 - 59
SICI:
0012-1797(1996)45:1<56:GNITMF>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPERIMENTAL DIABETIC NEUROPATHY; NERVE-CONDUCTION; MYELINATED FIBERS; SURAL-NERVE; COMPLICATIONS; INHIBITION; SORBITOL; RATS; INTOXICATION; PATHWAY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
S. Yagihashi et al., "GALACTOSEMIC NEUROPATHY IN TRANSGENIC MICE FOR HUMAN ALDOSE REDUCTASE", Diabetes, 45(1), 1996, pp. 56-59

Abstract

We studied the functional consequences of an enhanced polyol pathway activity, elicited with galactose feeding, on the peripheral nerve of transgenic mice expressing human aldose reductase, Nontransgenic littermate mice were used as controls. With a quantitative immunoassay, theexpression level of human aldose reductase in the sciatic nerve was 791 +/- 44 ng/mg protein (mean +/- SE), about 25% of that in human sural nerve, When the transgenic mice were fed food containing 30% galactose, significant levels of galactitol accumulated in the sciatic nerve. Galactose feeding of nontransgenic littermate mice led to a 10-fold lower accumulation of galactitol, Galactose feeding for 16 weeks causeda significant and progressive decrease in motor nerve conduction velocity in transgenic mice to 80% of the level of galactose-fed littermate mice, which was not significantly different from that of galactose-free littermate mice. A morphometric analysis of sciatic nerve detected>10% reduction of mean myelinated fiber size but no alterations of myelinated fiber density in galactose-fed transgenic mice compared with other groups, The functional and structural changes that develop in galactose-fed transgenic mice are similar to those previously reported in diabetic animals. The results of these studies suggest that transgenic mice expressing human aldose reductase may be a useful model not only for defining the role of the polyol pathway in diabetic neuropathy but also for identifying and characterizing effective inhibitors specific for human aldose reductase.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 08:44:18