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Titolo:
THE INFLUENCE OF CAPSULATION AND LIPOOLIGOSACCHARIDE STRUCTURE ON NEUTROPHIL ADHESION MOLECULE EXPRESSION AND ENDOTHELIAL INJURY BY NEISSERIA-MENINGITIDIS
Autore:
KLEIN NJ; ISON CA; PEAKMAN M; LEVIN M; HAMMERSCHMIDT S; FROSCH M; HEYDERMAN RS;
Indirizzi:
ST MARYS HOSP MED SCI,DEPT MED MICROBIOL,INST CHILD HLTH,IMMUNOBIOL UNIT,30 GUILFORD ST LONDON WC1N 1EH ENGLAND KINGS COLL SCH MED & DENT,DEPT IMMUNOL LONDON ENGLAND HANNOVER MED SCH,INST MED MIKROBIOL HANNOVER GERMANY
Titolo Testata:
The Journal of infectious diseases
fascicolo: 1, volume: 173, anno: 1996,
pagine: 172 - 179
SICI:
0022-1899(1996)173:1<172:TIOCAL>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYSTEMIC MENINGOCOCCAL DISEASE; TUMOR NECROSIS FACTOR; L-SELECTIN EXPRESSION; COMPLEMENT ACTIVATION; CHEMOTACTIC FACTORS; CELLS; ENDOTOXIN; CHILDREN; ELASTASE; LIPOPOLYSACCHARIDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
N.J. Klein et al., "THE INFLUENCE OF CAPSULATION AND LIPOOLIGOSACCHARIDE STRUCTURE ON NEUTROPHIL ADHESION MOLECULE EXPRESSION AND ENDOTHELIAL INJURY BY NEISSERIA-MENINGITIDIS", The Journal of infectious diseases, 173(1), 1996, pp. 172-179

Abstract

Host inflammatory response to meningococcal infection is believed to be a major determinant of disease severity, Isogenic mutants of Neisseria meningitidis serogroup B1940, which differ in expression of capsular polysaccharide and lipooligosaccharide (LOS), were used to examine host responses in a whole blood model of bacteremia and a model of endothelial injury. The parent organism caused significantly less neutrophil shedding of the adhesion molecule, L-selectin, than the three mutant organisms (P < .01) and was most resistant to the bactericidal activity of whole blood, Despite marked differences in bacterial adhesion to endothelial cells (P < .05), no damage was induced by organisms alone. Endothelial injury was observed when neutrophils were incubated with adherent, capsule-deficient organisms (P < .05). The degree of endothelial damage was related to the number of neutrophils adherent to the endothelium. Thus, bacterial capsulation and LOS structure can influence neutrophil activation and endothelial injury and, as such, may beimportant in the pathogenesis of meningococcal sepsis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/21 alle ore 03:55:39