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Titolo:
HEPATIC RETENTION OF COPPER AND SELENIUM IN PRIMARY SCLEROSING CHOLANGITIS
Autore:
AASETH J; THOMASSEN Y; AADLAND E; FAUSA O; SCHRUMPF E;
Indirizzi:
NATL INST OCCUPAT HLTH,POB 8149 DEP N-0033 OSLO NORWAY NATL INST OCCUPAT HLTH N-0033 OSLO NORWAY HEDMARK CENT HOSP,DEPT CLIN CHEM ELVERUM NORWAY NATL HOSP,DEPT INTERNAL MED OSLO NORWAY
Titolo Testata:
Scandinavian journal of gastroenterology
fascicolo: 12, volume: 30, anno: 1995,
pagine: 1200 - 1203
SICI:
0036-5521(1995)30:12<1200:HROCAS>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT; LIVER; EXCRETION; FEATURES; MEMBRANE; DISEASE; SERUM;
Keywords:
COPPER; PRIMARY SCLEROSING CHOLANGITIS; SELENIUM; TRACE ELEMENTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
J. Aaseth et al., "HEPATIC RETENTION OF COPPER AND SELENIUM IN PRIMARY SCLEROSING CHOLANGITIS", Scandinavian journal of gastroenterology, 30(12), 1995, pp. 1200-1203

Abstract

Background: Previous studies have suggested abnormal copper metabolism in patients with primary sclerosing cholangitis (PSC). In the present work the trace element metabolism was studied in a group of 32 patients with PSC. Methods: Hepatic copper and selenium concentrations weredetermined with a sensitive electrothermal atomic absorption technique. Serum concentrations of copper and zinc were determined by conventional atomic absorption. Results: For the patient group serum copper values (20.3 +/- 4.5 mu mol/l) were higher than those for the control group (14 +/- 3 mu mol/l), and average hepatic copper concentrations were greater by a factor of four. Serum selenium values were slightly lower, although the average hepatic selenium was significantly higher than in the healthy control group. Previous studies have discussed possible toxic effects of hepatocellular copper accumulation, which may be accompanied by formation of activated oxygen species and depletion of glutathione. In the present study, however, it could nor be demonstrated that the concentration of the lipoperoxidation product, malonic dialdehyde, was higher than normal in blood. Furthermore, blood concentrations of glutathione and glutathione peroxidase were not abnormal. Conclusion: Although a protective effect of the raised selenium concentrations in the liver might be discussed, it is apparent that the copper accumulation in the liver cells described here did not induce detectable changes in the indices studied.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 18:25:17