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Titolo:
REGULATION OF BILE-ACID SYNTHESIS IN HUMANS - STUDIES ON CHOLESTEROL 7-ALPHA-HYDROXYLATION IN-VIVO
Autore:
BERTOLOTTI M; ABATE N; LORIA P; CONCARI M; GUICCIARDI M; DILENGITE M; BOZZOLI M; CARUBBI F; CARULLI N;
Indirizzi:
UNIV MODENA,POLICLIN,IST PATOL MED,VIA POZZO 71 I-41100 MODENA ITALY UNIV MODENA,IST PATOL MED MODENA ITALY
Titolo Testata:
The Italian Journal of Gastroenterology
fascicolo: 8, volume: 27, anno: 1995,
pagine: 446 - 449
SICI:
0392-0623(1995)27:8<446:ROBSIH>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
7-ALPHA-HYDROXYLASE MESSENGER-RNA; BILIARY LIPID SECRETION; URSODEOXYCHOLIC ACID; HEPATIC CHOLESTEROL; METABOLISM; RAT; CLONING; INVIVO; LIVER; 7ALPHA-HYDROXYLASE;
Keywords:
CHENODEOXYCHOLIC ACID; CHOLESTYRAMINE; DEOXYCHOLIC ACID; HYPERLIPEMIA; SIMVASTATIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
M. Bertolotti et al., "REGULATION OF BILE-ACID SYNTHESIS IN HUMANS - STUDIES ON CHOLESTEROL 7-ALPHA-HYDROXYLATION IN-VIVO", The Italian Journal of Gastroenterology, 27(8), 1995, pp. 446-449

Abstract

Over the last few years important progress has been made on the quantitation of cholesterol 7 alpha-hydroxylation, the rate-limiting step of bile acid synthesis. The use of a technique based on the determination of body water tritium enrichment after i.v. administration of [7 alpha-H-3] cholesterol has allowed in vivo investigation of this step inhumans in different experimental conditions, The cholesterol 7 alpha-hydroxylation rate was not affected by the administration of the hydrophilic bile acid ursodeoxycholic acid (UDCA) whereas it was significantly reduced by the more hydrophobic chenodeoxycholic acid (CDCA) and even more so by the strongly hydrophobic deoxycholic acid (DCA). The administration of cholestyramine induced a significant dose-related increase of 7 alpha-hydroxylation along with a correspondent decrease in plasma cholesterol, The administration of simvastatin exerted no effecton cholesterol 7 alpha-hydroxylation despite a marked decrease in serum cholesterol, Treatment with fibrates reduced plasma lipid levels and 7 alpha-hydroxylation rates, Hydroxylation rates were unchanged in familial hypercholesterolaemia and increased in familial combined hyperlipidaemia. These data suggest that in humans bile acid synthesis can be affected by quantitative and qualitative alterations of the enterohepatic circulation of bile acids. Changes in cholesterol 7 alpha-hydroxylation rates may be associated with alterations in plasma lipid levels, bat such a relationship is ill-defined and seems to vary with the different experimental models.

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Documento generato il 29/11/20 alle ore 03:22:03